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Effects of gradual bone lengthening on the rabbit tibial nerve

Kerns, James; Urabe, Tadahisa; Bleasdale, Thomas; Zhao, Qing; Lundborg, Göran LU and Danielsen, Nils LU (2001) In Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00 35(4). p.361-368
Abstract
Little is known about the effect of gradual bone lengthening on peripheral nerves. In the present study, an external fixation device was applied to the rabbit tibia, which was then divided. After seven days, the tibia was subjected to 0.7 mm/day callus distraction for periods of up to one month. The tibial nerve was fixed in glutaraldehyde and plastic sections were cut in longitudinal and transverse planes for light and electron microscopy. Light microscopy showed a 64% increase in the gap length at the node of Ranvier in myelinated axons from the experimental side compared with the control side. The cross-sectional area of the non-myelinated axons was not altered significantly. We conclude that gradual stretching of the nerve elongates... (More)
Little is known about the effect of gradual bone lengthening on peripheral nerves. In the present study, an external fixation device was applied to the rabbit tibia, which was then divided. After seven days, the tibia was subjected to 0.7 mm/day callus distraction for periods of up to one month. The tibial nerve was fixed in glutaraldehyde and plastic sections were cut in longitudinal and transverse planes for light and electron microscopy. Light microscopy showed a 64% increase in the gap length at the node of Ranvier in myelinated axons from the experimental side compared with the control side. The cross-sectional area of the non-myelinated axons was not altered significantly. We conclude that gradual stretching of the nerve elongates the nerve fibres at least at the region of the nodes, perhaps a point of least resistance. Diameters of fibres seem to be held more constant during the lengthening procedure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone, Lengthening, Rabbit, Tibia, Tibial, Nerve, Node, Of, Ranvier
in
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00
volume
35
issue
4
pages
361 - 368
publisher
Taylor & Francis
external identifiers
  • wos:000173155800004
  • scopus:0035666061
ISSN
1651-2073
DOI
10.1080/028443101317149327
language
English
LU publication?
yes
id
d177925f-ad16-45cc-a78e-b6d8ab463afb (old id 1118531)
date added to LUP
2008-07-01 13:23:55
date last changed
2018-08-12 04:09:29
@article{d177925f-ad16-45cc-a78e-b6d8ab463afb,
  abstract     = {Little is known about the effect of gradual bone lengthening on peripheral nerves. In the present study, an external fixation device was applied to the rabbit tibia, which was then divided. After seven days, the tibia was subjected to 0.7 mm/day callus distraction for periods of up to one month. The tibial nerve was fixed in glutaraldehyde and plastic sections were cut in longitudinal and transverse planes for light and electron microscopy. Light microscopy showed a 64% increase in the gap length at the node of Ranvier in myelinated axons from the experimental side compared with the control side. The cross-sectional area of the non-myelinated axons was not altered significantly. We conclude that gradual stretching of the nerve elongates the nerve fibres at least at the region of the nodes, perhaps a point of least resistance. Diameters of fibres seem to be held more constant during the lengthening procedure.},
  author       = {Kerns, James and Urabe, Tadahisa and Bleasdale, Thomas and Zhao, Qing and Lundborg, Göran and Danielsen, Nils},
  issn         = {1651-2073},
  keyword      = {Bone,Lengthening,Rabbit,Tibia,Tibial,Nerve,Node,Of,Ranvier},
  language     = {eng},
  number       = {4},
  pages        = {361--368},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery1987-01-01+01:002010-01-01+01:00},
  title        = {Effects of gradual bone lengthening on the rabbit tibial nerve},
  url          = {http://dx.doi.org/10.1080/028443101317149327},
  volume       = {35},
  year         = {2001},
}