The 'innate' host response protects and damages the infected urinary tract
Svanborg, Catharina LU ; Bergsten, G ; Fischer, H ; Frendeus, B ; Godaly, Gabriela LU ; Gustafsson, E ; Hang, L ; Hedlund, M ; Karpman, Diana LU
and Lundstedt, A C
, et al.
(2001)
In Annals of Medicine
33(9).
p.563-570
- Abstract
- Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the defence. We have studied these issues in the urinary tract infection (UTI) model. The symptoms of UTI and the host defence both rely on the so-called 'innate' immune system, making this one of the best characterized human disease models of 'innate immunity. We discuss the critical molecular events that determine whether the host response will be activated by P-fimbriated uropathogenic Escherichia coli as well as factors... (More)
- Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the defence. We have studied these issues in the urinary tract infection (UTI) model. The symptoms of UTI and the host defence both rely on the so-called 'innate' immune system, making this one of the best characterized human disease models of 'innate immunity. We discuss the critical molecular events that determine whether the host response will be activated by P-fimbriated uropathogenic Escherichia coli as well as factors determining whether the patient develops acute pyelonephritis or asymptomatic bacteriuria. We will describe the glycoconjugate receptors used by the P-fimbriated bacteria adhering to host tissues, the recruitment of TLR4 co-receptors and the signalling pathways that allow progression to symptomatic disease, and discuss how these mechanisms are altered in asymptomatic carriers, presenting the possible genetic basis for unresponsiveness. We have shown that neutrophils are the critical effectors of the host defence and that neutrophil dysfunctions lead to acute pyelonephritis and renal scarring. Here we discuss the mechanisms of neutrophil-mediated, chemokine receptor (CXCR1)-dependent clearance, and the defect in interleukin-8 receptor homolog knock-out (IL-8Rh KO) mice and describe the data linking low CXCR1 expression to recurrent pyelonephritis in man, as well as the information on the genetic basis for low CXCR1 expression in affected patients. Finally, the mechanisms of renal scarring in IL8Rh KO mice will be discussed in relation to human disease. Our studies hold the promise to provide a molecular and genetic explanation for disease susceptibility in some patients with UTI and to offer more precise tools for the diagnosis and therapy of these infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119903
- author
- Svanborg, Catharina
LU
; Bergsten, G
; Fischer, H
; Frendeus, B
; Godaly, Gabriela
LU
; Gustafsson, E
; Hang, L
; Hedlund, M
; Karpman, Diana
LU
and Lundstedt, A C
, et al. (More)
- Svanborg, Catharina
LU
; Bergsten, G
; Fischer, H
; Frendeus, B
; Godaly, Gabriela
LU
; Gustafsson, E
; Hang, L
; Hedlund, M
; Karpman, Diana
LU
; Lundstedt, A C
; Samuelsson, M
; Samuelsson, P
; Svensson, Majlis
LU
and Wullt, B
(Less)
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Medicine
- volume
- 33
- issue
- 9
- pages
- 563 - 570
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:11817650
- scopus:0035682714
- ISSN
- 1365-2060
- language
- English
- LU publication?
- yes
- id
- fd6bb694-d777-47eb-b249-264f79a31511 (old id 1119903)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/11817650
- date added to LUP
- 2016-04-01 11:36:54
- date last changed
- 2022-01-26 07:37:34
@article{fd6bb694-d777-47eb-b249-264f79a31511,
abstract = {{Symptoms of infection and tissue pathology are caused by the host response; not by the microbe per se. The same response is also critical for the defence and is needed to clear infection. It is therefore essential to understand how the host response is activated and to identify the critical effector mechanisms of the defence. We have studied these issues in the urinary tract infection (UTI) model. The symptoms of UTI and the host defence both rely on the so-called 'innate' immune system, making this one of the best characterized human disease models of 'innate immunity. We discuss the critical molecular events that determine whether the host response will be activated by P-fimbriated uropathogenic Escherichia coli as well as factors determining whether the patient develops acute pyelonephritis or asymptomatic bacteriuria. We will describe the glycoconjugate receptors used by the P-fimbriated bacteria adhering to host tissues, the recruitment of TLR4 co-receptors and the signalling pathways that allow progression to symptomatic disease, and discuss how these mechanisms are altered in asymptomatic carriers, presenting the possible genetic basis for unresponsiveness. We have shown that neutrophils are the critical effectors of the host defence and that neutrophil dysfunctions lead to acute pyelonephritis and renal scarring. Here we discuss the mechanisms of neutrophil-mediated, chemokine receptor (CXCR1)-dependent clearance, and the defect in interleukin-8 receptor homolog knock-out (IL-8Rh KO) mice and describe the data linking low CXCR1 expression to recurrent pyelonephritis in man, as well as the information on the genetic basis for low CXCR1 expression in affected patients. Finally, the mechanisms of renal scarring in IL8Rh KO mice will be discussed in relation to human disease. Our studies hold the promise to provide a molecular and genetic explanation for disease susceptibility in some patients with UTI and to offer more precise tools for the diagnosis and therapy of these infections.}},
author = {{Svanborg, Catharina and Bergsten, G and Fischer, H and Frendeus, B and Godaly, Gabriela and Gustafsson, E and Hang, L and Hedlund, M and Karpman, Diana and Lundstedt, A C and Samuelsson, M and Samuelsson, P and Svensson, Majlis and Wullt, B}},
issn = {{1365-2060}},
language = {{eng}},
number = {{9}},
pages = {{563--570}},
publisher = {{Taylor & Francis}},
series = {{Annals of Medicine}},
title = {{The 'innate' host response protects and damages the infected urinary tract}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/11817650}},
volume = {{33}},
year = {{2001}},
}