Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor
(2001) In NeuroReport 12(10). p.2215-2219- Abstract
- The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after... (More)
- The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119993
- author
- Jongsma, Helen ; Pettersson, Lina LU ; Kvist Reimer, Martina LU ; Kanje, Martin LU ; Waldenström Ellervik, Alexandra LU ; Sundler, Frank LU and Danielsen, Nils LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dorsal root ganglion, Formalin test, Inflammation, Mechanical von Frey, Neuropeptides, PACAP, Pain measurements, Sciatic nerve injury, Sensory thresholds, Thermal laser
- in
- NeuroReport
- volume
- 12
- issue
- 10
- pages
- 2215 - 2219
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:11447337
- scopus:0035919848
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Functional Zoology (432112239), Neural Interfaces (013212003), Neurophysiology (013212004), Neuroendocrine Cell Biology (013212008), Faculty of Medicine (000022000)
- id
- 8d72410a-7f72-4d1c-9032-5537f12964bb (old id 1119993)
- date added to LUP
- 2016-04-01 12:09:50
- date last changed
- 2022-01-26 23:41:55
@article{8d72410a-7f72-4d1c-9032-5537f12964bb, abstract = {{The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.}}, author = {{Jongsma, Helen and Pettersson, Lina and Kvist Reimer, Martina and Kanje, Martin and Waldenström Ellervik, Alexandra and Sundler, Frank and Danielsen, Nils}}, issn = {{1473-558X}}, keywords = {{Dorsal root ganglion; Formalin test; Inflammation; Mechanical von Frey; Neuropeptides; PACAP; Pain measurements; Sciatic nerve injury; Sensory thresholds; Thermal laser}}, language = {{eng}}, number = {{10}}, pages = {{2215--2219}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor}}, volume = {{12}}, year = {{2001}}, }