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Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor

Jongsma, Helen; Pettersson, Lina LU ; Kvist Reimer, Martina LU ; Kanje, Martin LU ; Waldenström Ellervik, Alexandra LU ; Sundler, Frank LU and Danielsen, Nils LU (2001) In NeuroReport 12(10). p.2215-2219
Abstract
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after... (More)
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dorsal root ganglion, Formalin test, Inflammation, Mechanical von Frey, Neuropeptides, PACAP, Pain measurements, Sciatic nerve injury, Sensory thresholds, Thermal laser
in
NeuroReport
volume
12
issue
10
pages
2215 - 2219
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:11447337
  • scopus:0035919848
ISSN
1473-558X
language
English
LU publication?
yes
id
8d72410a-7f72-4d1c-9032-5537f12964bb (old id 1119993)
date added to LUP
2008-07-01 09:46:15
date last changed
2018-03-18 03:47:33
@article{8d72410a-7f72-4d1c-9032-5537f12964bb,
  abstract     = {The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.},
  author       = {Jongsma, Helen and Pettersson, Lina and Kvist Reimer, Martina and Kanje, Martin and Waldenström Ellervik, Alexandra and Sundler, Frank and Danielsen, Nils},
  issn         = {1473-558X},
  keyword      = {Dorsal root ganglion,Formalin test,Inflammation,Mechanical von Frey,Neuropeptides,PACAP,Pain measurements,Sciatic nerve injury,Sensory thresholds,Thermal laser},
  language     = {eng},
  number       = {10},
  pages        = {2215--2219},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor},
  volume       = {12},
  year         = {2001},
}