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Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.

Sjöberg, Klas LU ; Eriksson, Sten LU ; Tenngart, Birgitta; Roth, Bodil LU ; Leffler, Hakon LU and Stenberg, Pål (2002) In Autoimmunity 35(5). p.357-364
Abstract
issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against... (More)
issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Coeliac Disease, Endomysial Antibodies, Factor Xiii, Transglutaminase Antibodies
in
Autoimmunity
volume
35
issue
5
pages
357 - 364
publisher
Taylor & Francis
external identifiers
  • pmid:12515290
  • wos:000178871600008
  • scopus:1842866001
ISSN
0891-6934
DOI
10.1080/0891693021000005402
language
English
LU publication?
yes
id
9274ea3c-afd2-4287-8233-b156788941b5 (old id 112037)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12515290&dopt=AbstractPlus
date added to LUP
2007-07-30 16:31:32
date last changed
2017-01-01 07:26:01
@article{9274ea3c-afd2-4287-8233-b156788941b5,
  abstract     = {issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease.},
  author       = {Sjöberg, Klas and Eriksson, Sten and Tenngart, Birgitta and Roth, Bodil and Leffler, Hakon and Stenberg, Pål},
  issn         = {0891-6934},
  keyword      = {Autoimmunity,Coeliac Disease,Endomysial Antibodies,Factor Xiii,Transglutaminase Antibodies},
  language     = {eng},
  number       = {5},
  pages        = {357--364},
  publisher    = {Taylor & Francis},
  series       = {Autoimmunity},
  title        = {Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.},
  url          = {http://dx.doi.org/10.1080/0891693021000005402},
  volume       = {35},
  year         = {2002},
}