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Nerve regeneration enhancement by tourniquet

Widerberg, Annika LU ; Lundborg, Göran LU and Dahlin, Lars LU (2001) In Journal of Hand Surgery (British Volume) 26(4). p.347-351
Abstract
The use of tourniquet compression as a non-invasive method to enhance axonal regeneration was assessed in the rat sciatic nerve. One hind limb of the rat was subjected to compression by a tourniquet set at 300 mmHg for 30 or 120 min followed by bilateral test crush lesions performed either directly or after a conditioning interval of 3 or 6 days, with the non-compressed side serving as a control. Axonal regeneration distances were evaluated after 3 days by the pinch reflex test. We found that compression caused an increased outgrowth length of sensory axons compared to the controls. The effect was most obvious after 120 min of compression with a conditioning interval of 6 days. Tourniquet compression has a conditioning lesion effect on... (More)
The use of tourniquet compression as a non-invasive method to enhance axonal regeneration was assessed in the rat sciatic nerve. One hind limb of the rat was subjected to compression by a tourniquet set at 300 mmHg for 30 or 120 min followed by bilateral test crush lesions performed either directly or after a conditioning interval of 3 or 6 days, with the non-compressed side serving as a control. Axonal regeneration distances were evaluated after 3 days by the pinch reflex test. We found that compression caused an increased outgrowth length of sensory axons compared to the controls. The effect was most obvious after 120 min of compression with a conditioning interval of 6 days. Tourniquet compression has a conditioning lesion effect on peripheral nerve and may enhance nerve regeneration. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hand Surgery (British Volume)
volume
26
issue
4
pages
347 - 351
publisher
SAGE Publications
external identifiers
  • pmid:11469837
  • scopus:0034877459
ISSN
0266-7681
DOI
10.1054/jhsb.2001.0599
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Reconstructive Surgery (013240300)
id
6ffa7fa1-83ce-423f-b6eb-dacd5be9023b (old id 1121741)
date added to LUP
2016-04-01 16:45:14
date last changed
2020-09-07 08:15:46
@article{6ffa7fa1-83ce-423f-b6eb-dacd5be9023b,
  abstract     = {The use of tourniquet compression as a non-invasive method to enhance axonal regeneration was assessed in the rat sciatic nerve. One hind limb of the rat was subjected to compression by a tourniquet set at 300 mmHg for 30 or 120 min followed by bilateral test crush lesions performed either directly or after a conditioning interval of 3 or 6 days, with the non-compressed side serving as a control. Axonal regeneration distances were evaluated after 3 days by the pinch reflex test. We found that compression caused an increased outgrowth length of sensory axons compared to the controls. The effect was most obvious after 120 min of compression with a conditioning interval of 6 days. Tourniquet compression has a conditioning lesion effect on peripheral nerve and may enhance nerve regeneration.},
  author       = {Widerberg, Annika and Lundborg, Göran and Dahlin, Lars},
  issn         = {0266-7681},
  language     = {eng},
  number       = {4},
  pages        = {347--351},
  publisher    = {SAGE Publications},
  series       = {Journal of Hand Surgery (British Volume)},
  title        = {Nerve regeneration enhancement by tourniquet},
  url          = {http://dx.doi.org/10.1054/jhsb.2001.0599},
  doi          = {10.1054/jhsb.2001.0599},
  volume       = {26},
  year         = {2001},
}