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Changes in GABA(B) receptor immunoreactivity after recurrent seizures in rats

Kokaia, Zaal LU and Kokaia, Merab LU (2001) In Neuroscience Letters 315(1-2). p.85-88
Abstract
GABA(B) receptors play an important role in the excitability of neuronal networks and can influence seizure activity. Here we demonstrate for the first time that kindling, an animal model for human temporal lobe epilepsy, leads to both early and delayed changes of GABA(B) receptor immunoreactivity in hippocampal and cortical areas. We propose that the altered GABA(B) receptor levels might be a compensatory mechanism to reduce excitability induced by recurrent kindled seizures, or alternatively, may promote the development of kindled epilepsy.
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GABAB, GABA, Kindling, Immunoreactivity, Epilepsy, Rat
in
Neuroscience Letters
volume
315
issue
1-2
pages
85 - 88
publisher
Elsevier
external identifiers
  • pmid:11711221
  • scopus:0035940755
ISSN
0304-3940
DOI
10.1016/S0304-3940(01)02350-3
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Neurology, Lund (013027000)
id
7eb728bc-300c-41fe-babb-60e2fe12fb83 (old id 1121972)
date added to LUP
2016-04-01 11:41:35
date last changed
2020-01-12 08:25:00
@article{7eb728bc-300c-41fe-babb-60e2fe12fb83,
  abstract     = {GABA(B) receptors play an important role in the excitability of neuronal networks and can influence seizure activity. Here we demonstrate for the first time that kindling, an animal model for human temporal lobe epilepsy, leads to both early and delayed changes of GABA(B) receptor immunoreactivity in hippocampal and cortical areas. We propose that the altered GABA(B) receptor levels might be a compensatory mechanism to reduce excitability induced by recurrent kindled seizures, or alternatively, may promote the development of kindled epilepsy.},
  author       = {Kokaia, Zaal and Kokaia, Merab},
  issn         = {0304-3940},
  language     = {eng},
  number       = {1-2},
  pages        = {85--88},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Changes in GABA(B) receptor immunoreactivity after recurrent seizures in rats},
  url          = {http://dx.doi.org/10.1016/S0304-3940(01)02350-3},
  doi          = {10.1016/S0304-3940(01)02350-3},
  volume       = {315},
  year         = {2001},
}