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Upregulation of p75 neurotrophin receptor after stroke in mice does not contribute to differential vulnerability of striatal neurons

Andsberg, Gunnar LU ; Kokaia, Zaal LU and Lindvall, Olle LU (2001) In Experimental Neurology 169(2). p.351-363
Abstract
The survival of different neuron types and the expression of the p75 neurotrophin receptor (p75(NTR)) after focal cerebral ischemia were studied in the mouse striatum using immunocytochemical and histochemical techniques and stereological procedures. As assessed at 1 week after 30 min of middle cerebral artery occlusion, the order of vulnerability was projection neurons > parvalbumin-expressing interneurons > nitric oxide synthase-containing interneurons > cholinergic interneurons. Within the ischemic lesion, projection neurons were almost completely lost whereas cholinergic interneurons were spared. Calretinin-immunoreactive interneurons also seemed resistant to the insult. Expression of p75(NTR) was induced in cholinergic... (More)
The survival of different neuron types and the expression of the p75 neurotrophin receptor (p75(NTR)) after focal cerebral ischemia were studied in the mouse striatum using immunocytochemical and histochemical techniques and stereological procedures. As assessed at 1 week after 30 min of middle cerebral artery occlusion, the order of vulnerability was projection neurons > parvalbumin-expressing interneurons > nitric oxide synthase-containing interneurons > cholinergic interneurons. Within the ischemic lesion, projection neurons were almost completely lost whereas cholinergic interneurons were spared. Calretinin-immunoreactive interneurons also seemed resistant to the insult. Expression of p75(NTR) was induced in cholinergic interneurons within the lesioned area, raising the possibility of a protective action. However, the number of cholinergic interneurons was unaffected in p75(NTR) knockout mice subjected to the same ischemic insult. These quantitative data demonstrate that striatal neurons in the mouse are differentially susceptible to ischemic damage and argue against a significant role of p75(NTR) for the high resistance of cholinergic interneurons. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
p75 neurotrophin receptor, stereology, cholinergic interneurons, striatum, stroke
in
Experimental Neurology
volume
169
issue
2
pages
351 - 363
publisher
Academic Press
external identifiers
  • pmid:11358448
  • scopus:0034982491
ISSN
0014-4886
DOI
10.1006/exnr.2001.7646
language
English
LU publication?
yes
id
0581d5b0-d375-4205-9398-aa4e86259fc3 (old id 1121994)
date added to LUP
2008-06-23 16:16:40
date last changed
2018-01-07 05:35:31
@article{0581d5b0-d375-4205-9398-aa4e86259fc3,
  abstract     = {The survival of different neuron types and the expression of the p75 neurotrophin receptor (p75(NTR)) after focal cerebral ischemia were studied in the mouse striatum using immunocytochemical and histochemical techniques and stereological procedures. As assessed at 1 week after 30 min of middle cerebral artery occlusion, the order of vulnerability was projection neurons > parvalbumin-expressing interneurons > nitric oxide synthase-containing interneurons > cholinergic interneurons. Within the ischemic lesion, projection neurons were almost completely lost whereas cholinergic interneurons were spared. Calretinin-immunoreactive interneurons also seemed resistant to the insult. Expression of p75(NTR) was induced in cholinergic interneurons within the lesioned area, raising the possibility of a protective action. However, the number of cholinergic interneurons was unaffected in p75(NTR) knockout mice subjected to the same ischemic insult. These quantitative data demonstrate that striatal neurons in the mouse are differentially susceptible to ischemic damage and argue against a significant role of p75(NTR) for the high resistance of cholinergic interneurons.},
  author       = {Andsberg, Gunnar and Kokaia, Zaal and Lindvall, Olle},
  issn         = {0014-4886},
  keyword      = {p75 neurotrophin receptor,stereology,cholinergic interneurons,striatum,stroke},
  language     = {eng},
  number       = {2},
  pages        = {351--363},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Upregulation of p75 neurotrophin receptor after stroke in mice does not contribute to differential vulnerability of striatal neurons},
  url          = {http://dx.doi.org/10.1006/exnr.2001.7646},
  volume       = {169},
  year         = {2001},
}