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Toward clinical application of prompt gamma spectroscopy for in vivo monitoring of boron uptake in boron neutron capture therapy

Munck af Rosenschöld, Per LU ; Verbakel, W.; Ceberg, Crister LU ; Stecher-Rasmussen, F. and Persson, Bertil R LU (2001) In Medical Physics 28(5). p.787-795
Abstract
In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt gamma spectroscopy (PGS) is studied that potentially can be used for in vivo and noninvasive boron concentration determination at the time of the treatment. The technique is based upon measurement of gamma rays promptly emitted in the B-10(n, alpha)Li-7 and H-1(n, gamma)D-2 reactions. The aim of this work is to prepare the present setup for... (More)
In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt gamma spectroscopy (PGS) is studied that potentially can be used for in vivo and noninvasive boron concentration determination at the time of the treatment. The technique is based upon measurement of gamma rays promptly emitted in the B-10(n, alpha)Li-7 and H-1(n, gamma)D-2 reactions. The aim of this work is to prepare the present setup for clinical application as a monitor of boron uptake in BNCT patients. Therefore, a full calibration and a set of phantom experiments were performed in a clinical setting. Specifically, a nonuniform boron distribution was studied; a skin/dura, a larger blood vessel, and tumor within a head phantom was simulated. The results show that it is possible to determine a homogeneous boron concentration of 5 mug/g within +/-3% (1 standard deviation). In the nonuniform case, this work shows that the boron concentration can be determined through a multistep measurement procedure, however, with a somewhat higher uncertainty (similar to 10%). The present work forms the basis for a subsequent clinical application of the PGS setup aimed at in vivo monitoring of boron uptake. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Medical Physics
volume
28
issue
5
pages
787 - 795
publisher
American Association of Physicists in Medicine
external identifiers
  • scopus:0034999602
ISSN
0094-2405
language
English
LU publication?
yes
id
6e8eadba-7c92-4036-bf35-75a2835cf231 (old id 1122176)
date added to LUP
2008-06-23 13:23:55
date last changed
2018-05-29 10:33:27
@article{6e8eadba-7c92-4036-bf35-75a2835cf231,
  abstract     = {In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt gamma spectroscopy (PGS) is studied that potentially can be used for in vivo and noninvasive boron concentration determination at the time of the treatment. The technique is based upon measurement of gamma rays promptly emitted in the B-10(n, alpha)Li-7 and H-1(n, gamma)D-2 reactions. The aim of this work is to prepare the present setup for clinical application as a monitor of boron uptake in BNCT patients. Therefore, a full calibration and a set of phantom experiments were performed in a clinical setting. Specifically, a nonuniform boron distribution was studied; a skin/dura, a larger blood vessel, and tumor within a head phantom was simulated. The results show that it is possible to determine a homogeneous boron concentration of 5 mug/g within +/-3% (1 standard deviation). In the nonuniform case, this work shows that the boron concentration can be determined through a multistep measurement procedure, however, with a somewhat higher uncertainty (similar to 10%). The present work forms the basis for a subsequent clinical application of the PGS setup aimed at in vivo monitoring of boron uptake.},
  author       = {Munck af Rosenschöld, Per and Verbakel, W. and Ceberg, Crister and Stecher-Rasmussen, F. and Persson, Bertil R},
  issn         = {0094-2405},
  language     = {eng},
  number       = {5},
  pages        = {787--795},
  publisher    = {American Association of Physicists in Medicine},
  series       = {Medical Physics},
  title        = {Toward clinical application of prompt gamma spectroscopy for in vivo monitoring of boron uptake in boron neutron capture therapy},
  volume       = {28},
  year         = {2001},
}