Advanced

Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease

Andersson, Anders; Ankerst, Jaro LU ; Lindgren, Arne LU ; Larsson, Kerstin and Hultberg, Björn LU (2001) In Clinical Chemistry and Laboratory Medicine 39(3). p.229-233
Abstract
Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the... (More)
Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the concentration of total plasma homocysteine is discussed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Chemistry and Laboratory Medicine
volume
39
issue
3
pages
229 - 233
publisher
De Gruyter
external identifiers
  • pmid:11350020
  • scopus:0035040446
ISSN
1434-6621
language
English
LU publication?
yes
id
fd7c4a2b-9512-4e25-9e94-391501378a41 (old id 1122316)
date added to LUP
2008-06-23 15:43:00
date last changed
2018-05-29 10:31:03
@article{fd7c4a2b-9512-4e25-9e94-391501378a41,
  abstract     = {Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the concentration of total plasma homocysteine is discussed.},
  author       = {Andersson, Anders and Ankerst, Jaro and Lindgren, Arne and Larsson, Kerstin and Hultberg, Björn},
  issn         = {1434-6621},
  language     = {eng},
  number       = {3},
  pages        = {229--233},
  publisher    = {De Gruyter},
  series       = {Clinical Chemistry and Laboratory Medicine},
  title        = {Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease},
  volume       = {39},
  year         = {2001},
}