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Kidney cadmium as compared to other markers of cadmium exposure in workers at a secondary metal smelter

Börjesson, Jimmy; Gerhardsson, Lars LU ; Schutz, Andrejs; Perfekt, Roland LU ; Mattsson, Sören LU and Skerfving, Staffan LU (2001) In American Journal of Industrial Medicine 39(1). p.19-28
Abstract
BACKGROUND: The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. METHODS: The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N = 33), K-Cd was also determined. RESULTS: B-Cd (median 4.6; range 0.5-53 nmol/L), U-Cd (0. 29; 0.04-1.9 micromol/mol creatinine) and K-Cd (14; 3-61 microg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, significant associations (P<0. 001) were obtained between B-Cd and K-Cd (r = 0.70), U-Cd and K-Cd (r = 0.60) and between U-Cd and B-Cd (r = 0.62). Multiple regression analyses... (More)
BACKGROUND: The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. METHODS: The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N = 33), K-Cd was also determined. RESULTS: B-Cd (median 4.6; range 0.5-53 nmol/L), U-Cd (0. 29; 0.04-1.9 micromol/mol creatinine) and K-Cd (14; 3-61 microg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, significant associations (P<0. 001) were obtained between B-Cd and K-Cd (r = 0.70), U-Cd and K-Cd (r = 0.60) and between U-Cd and B-Cd (r = 0.62). Multiple regression analyses revealed smoking as the major predictor of K-Cd, B-Cd, and U-Cd. B-Cd and U-Cd were both associated with the duration of employment at the smelter. CONCLUSIONS: There was no statistically significant evidence of previous occupational exposure at the smelter from measurement of K-Cd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cadmium, smelter, lead, kidney, X-ray fluorescence, smoking
in
American Journal of Industrial Medicine
volume
39
issue
1
pages
19 - 28
publisher
John Wiley & Sons
external identifiers
  • pmid:11148012
  • scopus:0035153684
ISSN
0271-3586
DOI
10.1002/1097-0274(200101)39:1<19::AID-AJIM2>3.0.CO;2-Q
language
English
LU publication?
yes
id
a3fcb60f-d1a0-4156-a6e2-47c145409696 (old id 1122662)
date added to LUP
2008-06-25 12:52:31
date last changed
2018-05-29 10:47:08
@article{a3fcb60f-d1a0-4156-a6e2-47c145409696,
  abstract     = {BACKGROUND: The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. METHODS: The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N = 33), K-Cd was also determined. RESULTS: B-Cd (median 4.6; range 0.5-53 nmol/L), U-Cd (0. 29; 0.04-1.9 micromol/mol creatinine) and K-Cd (14; 3-61 microg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, significant associations (P&lt;0. 001) were obtained between B-Cd and K-Cd (r = 0.70), U-Cd and K-Cd (r = 0.60) and between U-Cd and B-Cd (r = 0.62). Multiple regression analyses revealed smoking as the major predictor of K-Cd, B-Cd, and U-Cd. B-Cd and U-Cd were both associated with the duration of employment at the smelter. CONCLUSIONS: There was no statistically significant evidence of previous occupational exposure at the smelter from measurement of K-Cd.},
  author       = {Börjesson, Jimmy and Gerhardsson, Lars and Schutz, Andrejs and Perfekt, Roland and Mattsson, Sören and Skerfving, Staffan},
  issn         = {0271-3586},
  keyword      = {cadmium,smelter,lead,kidney,X-ray fluorescence,smoking},
  language     = {eng},
  number       = {1},
  pages        = {19--28},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Industrial Medicine},
  title        = {Kidney cadmium as compared to other markers of cadmium exposure in workers at a secondary metal smelter},
  url          = {http://dx.doi.org/10.1002/1097-0274(200101)39:1<19::AID-AJIM2>3.0.CO;2-Q},
  volume       = {39},
  year         = {2001},
}