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Intergrated system for interstitial photodynamic therapy

Andersson-Engels, Stefan LU ; Bendsöe, Niels LU ; Johansson, Thomas; Pålsson, Sara LU ; Soto Thompson, Marcelo LU ; Stenram, Unne LU ; Svanberg, Katarina LU and Svanberg, Sune LU (2003) In Proceedings of SPIE 5123. p.293-302
Abstract
To develop PDT beyond treatment of thin superficial tumors, to also be an efficient treatment alternative to deeply located and/or thick tumors, a system based on interstitial illumination using multiple fibers has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumors and tumors in the oral cavity. In interstitial PDT one needs to use multiple fibers for light delivery in order to allow treatments of tumors larger than a few millimeters in diameter. Our sytem consists of a laser light source, a beam-splitting system dividing the light into three or six output fibers and a custom-made dosimetry program. The concept is then to use these fibers not only for delivering the... (More)
To develop PDT beyond treatment of thin superficial tumors, to also be an efficient treatment alternative to deeply located and/or thick tumors, a system based on interstitial illumination using multiple fibers has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumors and tumors in the oral cavity. In interstitial PDT one needs to use multiple fibers for light delivery in order to allow treatments of tumors larger than a few millimeters in diameter. Our sytem consists of a laser light source, a beam-splitting system dividing the light into three or six output fibers and a custom-made dosimetry program. The concept is then to use these fibers not only for delivering the treatment light, but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fiber is measured at the positions of the other fiber tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumors have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Proceedings of SPIE
volume
5123
pages
293 - 302
publisher
SPIE
external identifiers
  • Scopus:0344081990
DOI
10.1117/12.517035
language
English
LU publication?
yes
id
4265ec99-7423-4ec7-9587-359aaf54741c (old id 1126731)
date added to LUP
2008-06-02 11:07:28
date last changed
2017-01-01 08:05:52
@article{4265ec99-7423-4ec7-9587-359aaf54741c,
  abstract     = {To develop PDT beyond treatment of thin superficial tumors, to also be an efficient treatment alternative to deeply located and/or thick tumors, a system based on interstitial illumination using multiple fibers has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumors and tumors in the oral cavity. In interstitial PDT one needs to use multiple fibers for light delivery in order to allow treatments of tumors larger than a few millimeters in diameter. Our sytem consists of a laser light source, a beam-splitting system dividing the light into three or six output fibers and a custom-made dosimetry program. The concept is then to use these fibers not only for delivering the treatment light, but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fiber is measured at the positions of the other fiber tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumors have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response.},
  author       = {Andersson-Engels, Stefan and Bendsöe, Niels and Johansson, Thomas and Pålsson, Sara and Soto Thompson, Marcelo and Stenram, Unne and Svanberg, Katarina and Svanberg, Sune},
  language     = {eng},
  pages        = {293--302},
  publisher    = {SPIE},
  series       = {Proceedings of SPIE},
  title        = {Intergrated system for interstitial photodynamic therapy},
  url          = {http://dx.doi.org/10.1117/12.517035},
  volume       = {5123},
  year         = {2003},
}