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Lakuäre Infarkte

Norrving, Bo LU (2003) In Therapeutische Umschau 60(9). p.535-540
Abstract
Lacunar infarcts, small deep infarcts resulting from occlusion of a penetrating artery, account for about a quarter of all ischemic strokes. The view of lacunar infarcts as a benign and rather innocent vascular lesion has been modified during the last years. Although the prognosis is more favourable than other subtypes during the first years, probably due to the small lesion size, in a longer perspective there is an excess risk of death, continual occurrence of recurrent stroke, and development of cognitive dysfunction. The risk of recurrent stroke is similar to most other types of stroke, and patients are at increased risk to develop cognitive decline and dementia. Increasing age, vascular risk factors, and high nocturnal blood pressure... (More)
Lacunar infarcts, small deep infarcts resulting from occlusion of a penetrating artery, account for about a quarter of all ischemic strokes. The view of lacunar infarcts as a benign and rather innocent vascular lesion has been modified during the last years. Although the prognosis is more favourable than other subtypes during the first years, probably due to the small lesion size, in a longer perspective there is an excess risk of death, continual occurrence of recurrent stroke, and development of cognitive dysfunction. The risk of recurrent stroke is similar to most other types of stroke, and patients are at increased risk to develop cognitive decline and dementia. Increasing age, vascular risk factors, and high nocturnal blood pressure have significant prognostic implications for almost all outcomes. Lacunar infarcts and ischemic white-matter disease, the two main types of cerebral small-vessel disease, frequently co-exist and have synergistic effects on prognosis and risk of cognitive decline. Antiplatelet therapy and risk factor modification are the cornerstones in secondary prevention after a lacunar infarct. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Therapeutische Umschau
volume
60
issue
9
pages
535 - 540
publisher
Huber
external identifiers
  • pmid:14579622
  • scopus:0141515793
ISSN
0040-5930
DOI
10.1024/0040-5930.60.9.535
language
German
LU publication?
yes
id
7e74e658-b219-4914-bfd0-924d759350b0 (old id 1127867)
date added to LUP
2008-06-04 14:11:45
date last changed
2018-07-01 04:19:08
@article{7e74e658-b219-4914-bfd0-924d759350b0,
  abstract     = {Lacunar infarcts, small deep infarcts resulting from occlusion of a penetrating artery, account for about a quarter of all ischemic strokes. The view of lacunar infarcts as a benign and rather innocent vascular lesion has been modified during the last years. Although the prognosis is more favourable than other subtypes during the first years, probably due to the small lesion size, in a longer perspective there is an excess risk of death, continual occurrence of recurrent stroke, and development of cognitive dysfunction. The risk of recurrent stroke is similar to most other types of stroke, and patients are at increased risk to develop cognitive decline and dementia. Increasing age, vascular risk factors, and high nocturnal blood pressure have significant prognostic implications for almost all outcomes. Lacunar infarcts and ischemic white-matter disease, the two main types of cerebral small-vessel disease, frequently co-exist and have synergistic effects on prognosis and risk of cognitive decline. Antiplatelet therapy and risk factor modification are the cornerstones in secondary prevention after a lacunar infarct.},
  author       = {Norrving, Bo},
  issn         = {0040-5930},
  language     = {ger},
  number       = {9},
  pages        = {535--540},
  publisher    = {Huber},
  series       = {Therapeutische Umschau},
  title        = {Lakuäre Infarkte},
  url          = {http://dx.doi.org/10.1024/0040-5930.60.9.535},
  volume       = {60},
  year         = {2003},
}