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Trombolys vid akut ischemisk stroke. Kritisk analys av aktuell kunskapsfront

Murray, Veronica; Norrving, Bo LU ; Terent, Andreas and Wester, Per (2004) In Läkartidningen 101(8). p.662-673
Abstract
Thrombolysis is a highly promising treatment in acute ischaemic stroke. There is evidence of positive effects at least up to three hours and most probably up to six. The risk of intracranial haemorrhage is increased fourfold with thrombolysis; risk factors other than the treatment as such have not been identified for certain; the risk is not related to giving thrombolysis during the 0-3 as opposed to the 3-6 hour time window. There is a non-significant excess of deaths, ranging from a small reduction to a substantial excess. There is not enough evidence to answer several questions regarding the influence of patient- and stroke characteristics on effectsize; death; and risk of intracranial haemorrhage. Giving priority to new large... (More)
Thrombolysis is a highly promising treatment in acute ischaemic stroke. There is evidence of positive effects at least up to three hours and most probably up to six. The risk of intracranial haemorrhage is increased fourfold with thrombolysis; risk factors other than the treatment as such have not been identified for certain; the risk is not related to giving thrombolysis during the 0-3 as opposed to the 3-6 hour time window. There is a non-significant excess of deaths, ranging from a small reduction to a substantial excess. There is not enough evidence to answer several questions regarding the influence of patient- and stroke characteristics on effectsize; death; and risk of intracranial haemorrhage. Giving priority to new large randomized controlled trials is essential to achieve this knowledge. (Less)
Please use this url to cite or link to this publication:
author
organization
alternative title
[Thrombolytic therapy in acute ischemic stroke. Critical analysis of current knowledge]
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
101
issue
8
pages
662 - 673
publisher
Swedish Medical Association
external identifiers
  • pmid:15024939
  • scopus:1642418894
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
fec22fef-4e9e-4691-b33e-2bc1431109b9 (old id 1130679)
alternative location
http://ltarkiv.lakartidningen.se/artNo28089
date added to LUP
2008-06-17 10:57:27
date last changed
2017-01-01 07:04:07
@article{fec22fef-4e9e-4691-b33e-2bc1431109b9,
  abstract     = {Thrombolysis is a highly promising treatment in acute ischaemic stroke. There is evidence of positive effects at least up to three hours and most probably up to six. The risk of intracranial haemorrhage is increased fourfold with thrombolysis; risk factors other than the treatment as such have not been identified for certain; the risk is not related to giving thrombolysis during the 0-3 as opposed to the 3-6 hour time window. There is a non-significant excess of deaths, ranging from a small reduction to a substantial excess. There is not enough evidence to answer several questions regarding the influence of patient- and stroke characteristics on effectsize; death; and risk of intracranial haemorrhage. Giving priority to new large randomized controlled trials is essential to achieve this knowledge.},
  author       = {Murray, Veronica and Norrving, Bo and Terent, Andreas and Wester, Per},
  issn         = {0023-7205},
  language     = {swe},
  number       = {8},
  pages        = {662--673},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Trombolys vid akut ischemisk stroke. Kritisk analys av aktuell kunskapsfront},
  volume       = {101},
  year         = {2004},
}