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Generalization of rapidly recurring seizures is suppressed in mice lacking glial cell line-derived neurotrophic factor family receptor alpha2.

Nanobashvili, Avtandil LU ; Kokaia, Zaal LU and Lindvall, Olle LU (2003) In Neuroscience 118(3). p.845-852
Abstract
Recent experimental evidence indicates that neurotrophic factors play a role in the pathophysiology of epilepsy. The objective of this study was to explore whether signaling through one of the glial cell line-derived neurotrophic factor family receptors, GFRα2, influences the severity of kindling-evoked, rapidly recurring seizures and the subsequent development of permanent hyperexcitability. We applied the rapid kindling model to adult mice, using 40 threshold stimulations delivered with 5-min interval in the ventral hippocampus. Generalized seizures were fewer and developed later in response to kindling stimulations in mice lacking GFRα2. However, GFRα2 gene deletion did not influence the acquisition of the permanent abnormal... (More)
Recent experimental evidence indicates that neurotrophic factors play a role in the pathophysiology of epilepsy. The objective of this study was to explore whether signaling through one of the glial cell line-derived neurotrophic factor family receptors, GFRα2, influences the severity of kindling-evoked, rapidly recurring seizures and the subsequent development of permanent hyperexcitability. We applied the rapid kindling model to adult mice, using 40 threshold stimulations delivered with 5-min interval in the ventral hippocampus. Generalized seizures were fewer and developed later in response to kindling stimulations in mice lacking GFRα2. However, GFRα2 gene deletion did not influence the acquisition of the permanent abnormal excitability as assessed 4 weeks later. In situ hybridization revealed marked and dynamic changes of GFRα2 mRNA levels in several forebrain areas following the stimulus-evoked seizures. Our findings provide evidence that signaling through the GFRα2 receptor contributes to seizure generalization in rapid kindling. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurotrophic factors, gene regulation, epilepsy, transgenic mice, in situ hybridization, kindling
in
Neuroscience
volume
118
issue
3
pages
845 - 852
publisher
Elsevier
external identifiers
  • wos:000182609700023
  • pmid:12710991
  • scopus:0037466777
ISSN
1873-7544
DOI
10.1016/S0306-4522(02)00998-3
language
English
LU publication?
yes
id
388e5630-7c4c-4309-9050-0ff1cd2e4579 (old id 113192)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12710991&dopt=Abstract
date added to LUP
2007-06-26 11:27:23
date last changed
2018-10-03 11:09:21
@article{388e5630-7c4c-4309-9050-0ff1cd2e4579,
  abstract     = {Recent experimental evidence indicates that neurotrophic factors play a role in the pathophysiology of epilepsy. The objective of this study was to explore whether signaling through one of the glial cell line-derived neurotrophic factor family receptors, GFRα2, influences the severity of kindling-evoked, rapidly recurring seizures and the subsequent development of permanent hyperexcitability. We applied the rapid kindling model to adult mice, using 40 threshold stimulations delivered with 5-min interval in the ventral hippocampus. Generalized seizures were fewer and developed later in response to kindling stimulations in mice lacking GFRα2. However, GFRα2 gene deletion did not influence the acquisition of the permanent abnormal excitability as assessed 4 weeks later. In situ hybridization revealed marked and dynamic changes of GFRα2 mRNA levels in several forebrain areas following the stimulus-evoked seizures. Our findings provide evidence that signaling through the GFRα2 receptor contributes to seizure generalization in rapid kindling.},
  author       = {Nanobashvili, Avtandil and Kokaia, Zaal and Lindvall, Olle},
  issn         = {1873-7544},
  keyword      = {neurotrophic factors,gene regulation,epilepsy,transgenic mice,in situ hybridization,kindling},
  language     = {eng},
  number       = {3},
  pages        = {845--852},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Generalization of rapidly recurring seizures is suppressed in mice lacking glial cell line-derived neurotrophic factor family receptor alpha2.},
  url          = {http://dx.doi.org/10.1016/S0306-4522(02)00998-3},
  volume       = {118},
  year         = {2003},
}