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Effects of aluminium chloride added to common patch test substances

Comstedt, Lisbeth Rosholm LU ; Siemund, Ingrid LU ; Dahlin, Jakob LU ; Bruze, Magnus LU and Svedman, Cecilia LU (2023) In Contact Dermatitis 88(6). p.456-462
Abstract

Background: A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. Objectives: The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Materials and methods: Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank... (More)

Background: A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. Objectives: The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Materials and methods: Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank test was used to calculate pairwise comparison in summarized test score for the preparations with MI and FM I. Results: Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compared to MI without Al-Cl. No differences in patch reactivity were noticed when adding Al-Cl to FM I. Conclusion: Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adjuvants, allergic contact dermatitis, irritants, mixes with aluminium, patch testing with metals, sensitivity, specificity
in
Contact Dermatitis
volume
88
issue
6
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85150649392
  • pmid:36840428
ISSN
0105-1873
DOI
10.1111/cod.14299
language
English
LU publication?
yes
id
1131cf5c-3333-453e-a8d0-be663e5dafbc
date added to LUP
2023-05-29 13:17:20
date last changed
2024-04-19 22:21:43
@article{1131cf5c-3333-453e-a8d0-be663e5dafbc,
  abstract     = {{<p>Background: A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. Objectives: The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Materials and methods: Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank test was used to calculate pairwise comparison in summarized test score for the preparations with MI and FM I. Results: Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compared to MI without Al-Cl. No differences in patch reactivity were noticed when adding Al-Cl to FM I. Conclusion: Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua.</p>}},
  author       = {{Comstedt, Lisbeth Rosholm and Siemund, Ingrid and Dahlin, Jakob and Bruze, Magnus and Svedman, Cecilia}},
  issn         = {{0105-1873}},
  keywords     = {{adjuvants; allergic contact dermatitis; irritants; mixes with aluminium; patch testing with metals; sensitivity; specificity}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{456--462}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Effects of aluminium chloride added to common patch test substances}},
  url          = {{http://dx.doi.org/10.1111/cod.14299}},
  doi          = {{10.1111/cod.14299}},
  volume       = {{88}},
  year         = {{2023}},
}