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Phospholipid signals and intestinal carcinogenesis

Duan, Rui-Dong LU (2006) In Scandinavian Journal of Food and Nutrition 50(S2). p.45-53
Abstract
Phospholipids are an important constituent of the cell plasma membrane and are also present in most

common dietary products, being particularly abundant in milk, egg, meat and beans. Phospholipids are

hydrolysed by different phospholipases to generate multiple breakdown products that affect the fate of the

cells. Most phospholipids such as phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol and

platelet activating factor are important for cell survival and thus may promote tumorigenesis and

inflammation. Sphingomyelin is unique in the sense that its hydrolysis by sphingomyelinase and ceramidase

generates several lipid messengers such as ceramide and sphingosine that... (More)
Phospholipids are an important constituent of the cell plasma membrane and are also present in most

common dietary products, being particularly abundant in milk, egg, meat and beans. Phospholipids are

hydrolysed by different phospholipases to generate multiple breakdown products that affect the fate of the

cells. Most phospholipids such as phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol and

platelet activating factor are important for cell survival and thus may promote tumorigenesis and

inflammation. Sphingomyelin is unique in the sense that its hydrolysis by sphingomyelinase and ceramidase

generates several lipid messengers such as ceramide and sphingosine that inhibit cell proliferation and induce

apoptosis. In the intestinal tract there is a specific type of sphingomyelinase called alkaline sphingomyelinase,

which can hydrolyse sphingomyelin in both the cell membrane and the diet. The enzyme may play important

roles in preventing colon cancer development and inflammation by hydrolysing sphingomyelin to generate

anticancer molecules, and by counteracting the cancer-promoting effects of other phospholipids such as

lysophosphatidylcholine and platelet activating factor. This mini-review highlights the signal transduction

pathways activated by different phospholipids, with special attention being paid to potential implications in

the development of colon cancer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colon cancer, inflammatory bowel disease, phospholipids, signal transduction pathway, sphingomyelin, sphingomyelinase
in
Scandinavian Journal of Food and Nutrition
volume
50
issue
S2
pages
45 - 53
publisher
Taylor & Francis
external identifiers
  • scopus:33845892131
ISSN
1748-2976
DOI
10.1080/17482970601075703
language
English
LU publication?
yes
id
854fa190-ccef-4e85-90c6-d78e2e39b068 (old id 1135708)
date added to LUP
2016-04-01 11:38:35
date last changed
2020-10-27 03:00:20
@article{854fa190-ccef-4e85-90c6-d78e2e39b068,
  abstract     = {Phospholipids are an important constituent of the cell plasma membrane and are also present in most<br/><br>
common dietary products, being particularly abundant in milk, egg, meat and beans. Phospholipids are<br/><br>
hydrolysed by different phospholipases to generate multiple breakdown products that affect the fate of the<br/><br>
cells. Most phospholipids such as phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol and<br/><br>
platelet activating factor are important for cell survival and thus may promote tumorigenesis and<br/><br>
inflammation. Sphingomyelin is unique in the sense that its hydrolysis by sphingomyelinase and ceramidase<br/><br>
generates several lipid messengers such as ceramide and sphingosine that inhibit cell proliferation and induce<br/><br>
apoptosis. In the intestinal tract there is a specific type of sphingomyelinase called alkaline sphingomyelinase,<br/><br>
which can hydrolyse sphingomyelin in both the cell membrane and the diet. The enzyme may play important<br/><br>
roles in preventing colon cancer development and inflammation by hydrolysing sphingomyelin to generate<br/><br>
anticancer molecules, and by counteracting the cancer-promoting effects of other phospholipids such as<br/><br>
lysophosphatidylcholine and platelet activating factor. This mini-review highlights the signal transduction<br/><br>
pathways activated by different phospholipids, with special attention being paid to potential implications in<br/><br>
the development of colon cancer.},
  author       = {Duan, Rui-Dong},
  issn         = {1748-2976},
  language     = {eng},
  number       = {S2},
  pages        = {45--53},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Food and Nutrition},
  title        = {Phospholipid signals and intestinal carcinogenesis},
  url          = {http://dx.doi.org/10.1080/17482970601075703},
  doi          = {10.1080/17482970601075703},
  volume       = {50},
  year         = {2006},
}