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Restless legs - vanligt sjukdomstillstånd som ofta missas. Möjligheter till framgångsrik behandling finns idag

Ekbom, Karl ; Leissner, Lena ; Olsson, Jan-Edvin and Widner, Håkan LU (2006) In Läkartidningen 103(4). p.207-211
Abstract
Restless legs syndrome (RLS) is characterized by intense restlessness and unpleasant creeping sensations deep inside the lower legs. The symptoms appear when the limbs are at rest and are worst in the evening and at night. They force the patients to keep moving their legs, and sometimes to get out of bed and wander about. Periodic limb movements of the extremities (PLM) are common during sleep thus causing severe reduction in sleep efficiency. In many cases RLS may be an inherited disorder and there is a common association with iron deficiency anemia and chronic renal failure. The pathophysiology of RLS is multifactorial and incompletely understood. Results of dopaminergic treatment and recent data by advanced neuroimaging suggest that... (More)
Restless legs syndrome (RLS) is characterized by intense restlessness and unpleasant creeping sensations deep inside the lower legs. The symptoms appear when the limbs are at rest and are worst in the evening and at night. They force the patients to keep moving their legs, and sometimes to get out of bed and wander about. Periodic limb movements of the extremities (PLM) are common during sleep thus causing severe reduction in sleep efficiency. In many cases RLS may be an inherited disorder and there is a common association with iron deficiency anemia and chronic renal failure. The pathophysiology of RLS is multifactorial and incompletely understood. Results of dopaminergic treatment and recent data by advanced neuroimaging suggest that symptoms of RLS may be generated in the central nervous system, notably in substantia nigra, putamen and by rhythmically active nuclei in the thalamus, brainstem and cerebellum. RLS is a very common disorder but has not seldom been under-diagnosed and poorly treated for many years in general practice. At present there is a wide range of treatment options including levodopa, dopamine agonists, opioids, antiepileptic drugs and benzodiazepines. (Less)
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author
; ; and
organization
alternative title
Restless legs--common but often missed disease. Successful treatment possibilities are now available
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
103
issue
4
pages
207 - 211
publisher
Swedish Medical Association
external identifiers
  • pmid:16491552
  • scopus:33644856114
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
0690cc30-07c8-40b4-881e-5f0bddf07f5f (old id 1135767)
alternative location
http://ltarkiv.lakartidningen.se/2006/temp/pda31236.pdf
date added to LUP
2016-04-01 15:46:21
date last changed
2020-04-22 03:25:14
@article{0690cc30-07c8-40b4-881e-5f0bddf07f5f,
  abstract     = {Restless legs syndrome (RLS) is characterized by intense restlessness and unpleasant creeping sensations deep inside the lower legs. The symptoms appear when the limbs are at rest and are worst in the evening and at night. They force the patients to keep moving their legs, and sometimes to get out of bed and wander about. Periodic limb movements of the extremities (PLM) are common during sleep thus causing severe reduction in sleep efficiency. In many cases RLS may be an inherited disorder and there is a common association with iron deficiency anemia and chronic renal failure. The pathophysiology of RLS is multifactorial and incompletely understood. Results of dopaminergic treatment and recent data by advanced neuroimaging suggest that symptoms of RLS may be generated in the central nervous system, notably in substantia nigra, putamen and by rhythmically active nuclei in the thalamus, brainstem and cerebellum. RLS is a very common disorder but has not seldom been under-diagnosed and poorly treated for many years in general practice. At present there is a wide range of treatment options including levodopa, dopamine agonists, opioids, antiepileptic drugs and benzodiazepines.},
  author       = {Ekbom, Karl and Leissner, Lena and Olsson, Jan-Edvin and Widner, Håkan},
  issn         = {0023-7205},
  language     = {swe},
  number       = {4},
  pages        = {207--211},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Restless legs - vanligt sjukdomstillstånd som ofta missas. Möjligheter till framgångsrik behandling finns idag},
  url          = {http://ltarkiv.lakartidningen.se/2006/temp/pda31236.pdf},
  volume       = {103},
  year         = {2006},
}