Celiaki som modell för autoimmun sjukdom. Transglutaminas har nyckelroll--stressreaktion sätter fart på ond cirkel
Roth, Bodil LU ; Sjöberg, Klas LU
and Stenberg, Pål
LU
(2006)
In Läkartidningen
103(19).
p.1523-1526
- Abstract
- The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated... (More)
- The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated gliadine may trigger the T-cells in persons with HLA DQ2/DQ8, generating antibodies against both transglutaminase and gliadin. Furthermore, the resulting villous atrophy decreases the absorption of zinc, thus causing a vicious circle. In rheumatoid arthritis a similar pattern is observed with the formation of antibodies against citrulline as well as against the calcium-dependent citrullinating thiol-enzyme, peptidylargininedeiminase, which also is inhibited by zinc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1135867
- author
- Roth, Bodil
LU
; Sjöberg, Klas
LU
and Stenberg, Pål
LU
- organization
- alternative title
- Celiac disease as a model for autoimmune disease. Transglutaminase has the key role--stress reaction triggers the vicious circle
- publishing date
- 2006
- type
- Contribution to specialist publication or newspaper
- publication status
- published
- subject
- keywords
- Glutenintolerans, Transglutaminaser, Autoimmuna sjukdomar
- in
- Läkartidningen
- volume
- 103
- issue
- 19
- pages
- 1523 - 1526
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:16805248
- scopus:33745286261
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 029a5f58-3e04-430f-869c-3b11887bd1df (old id 1135867)
- alternative location
- http://www.lakartidningen.se/OldWebArticlePdf/3/3988/LKT0619s1523_1526.pdf
- date added to LUP
- 2016-04-01 15:35:24
- date last changed
- 2023-04-08 18:07:36
@misc{029a5f58-3e04-430f-869c-3b11887bd1df,
abstract = {{The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated gliadine may trigger the T-cells in persons with HLA DQ2/DQ8, generating antibodies against both transglutaminase and gliadin. Furthermore, the resulting villous atrophy decreases the absorption of zinc, thus causing a vicious circle. In rheumatoid arthritis a similar pattern is observed with the formation of antibodies against citrulline as well as against the calcium-dependent citrullinating thiol-enzyme, peptidylargininedeiminase, which also is inhibited by zinc.}},
author = {{Roth, Bodil and Sjöberg, Klas and Stenberg, Pål}},
issn = {{0023-7205}},
keywords = {{Glutenintolerans; Transglutaminaser; Autoimmuna sjukdomar}},
language = {{swe}},
number = {{19}},
pages = {{1523--1526}},
publisher = {{Swedish Medical Association}},
series = {{Läkartidningen}},
title = {{Celiaki som modell för autoimmun sjukdom. Transglutaminas har nyckelroll--stressreaktion sätter fart på ond cirkel}},
url = {{http://www.lakartidningen.se/OldWebArticlePdf/3/3988/LKT0619s1523_1526.pdf}},
volume = {{103}},
year = {{2006}},
}