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Celiaki som modell för autoimmun sjukdom. Transglutaminas har nyckelroll--stressreaktion sätter fart på ond cirkel

Roth, Bodil ; Sjöberg, Klas LU and Stenberg, Pål LU (2006) In Läkartidningen 103(19). p.1523-1526
Abstract
The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated... (More)
The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated gliadine may trigger the T-cells in persons with HLA DQ2/DQ8, generating antibodies against both transglutaminase and gliadin. Furthermore, the resulting villous atrophy decreases the absorption of zinc, thus causing a vicious circle. In rheumatoid arthritis a similar pattern is observed with the formation of antibodies against citrulline as well as against the calcium-dependent citrullinating thiol-enzyme, peptidylargininedeiminase, which also is inhibited by zinc. (Less)
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author
; and
organization
alternative title
Celiac disease as a model for autoimmune disease. Transglutaminase has the key role--stress reaction triggers the vicious circle
publishing date
type
Contribution to specialist publication or newspaper
publication status
published
subject
keywords
Glutenintolerans, Transglutaminaser, Autoimmuna sjukdomar
in
Läkartidningen
volume
103
issue
19
pages
1523 - 1526
publisher
Swedish Medical Association
external identifiers
  • pmid:16805248
  • scopus:33745286261
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
029a5f58-3e04-430f-869c-3b11887bd1df (old id 1135867)
alternative location
http://www.lakartidningen.se/OldWebArticlePdf/3/3988/LKT0619s1523_1526.pdf
date added to LUP
2016-04-01 15:35:24
date last changed
2021-02-17 07:08:27
@misc{029a5f58-3e04-430f-869c-3b11887bd1df,
  abstract     = {The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if accidentally activated, for example due to a stress-induced low concentration of intestinal zinc, tissue transglutaminase will sequentially deamidate specific glutamine residues in gliadins. During this process, an abnormally long-lived thioester intermediate between the active site cysteine of the enzyme and a previously, partly deamidated gliadine may trigger the T-cells in persons with HLA DQ2/DQ8, generating antibodies against both transglutaminase and gliadin. Furthermore, the resulting villous atrophy decreases the absorption of zinc, thus causing a vicious circle. In rheumatoid arthritis a similar pattern is observed with the formation of antibodies against citrulline as well as against the calcium-dependent citrullinating thiol-enzyme, peptidylargininedeiminase, which also is inhibited by zinc.},
  author       = {Roth, Bodil and Sjöberg, Klas and Stenberg, Pål},
  issn         = {0023-7205},
  language     = {swe},
  number       = {19},
  pages        = {1523--1526},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Celiaki som modell för autoimmun sjukdom. Transglutaminas har nyckelroll--stressreaktion sätter fart på ond cirkel},
  url          = {http://www.lakartidningen.se/OldWebArticlePdf/3/3988/LKT0619s1523_1526.pdf},
  volume       = {103},
  year         = {2006},
}