Leukotriene D4-induced calcium signaling in human intestinal epithelial cells.
(2002) 507. p.187-191- Abstract
- LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and... (More)
- LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/113683
- author
- Thodeti, Charles Kumar and Sjölander, Anita LU
- organization
- publishing date
- 2002
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 (Advances in Experimental Medicine and Biology)
- volume
- 507
- pages
- 187 - 191
- publisher
- Springer
- external identifiers
-
- pmid:12664584
- wos:000181518300029
- scopus:0038784265
- ISSN
- 0065-2598
- ISBN
- 978-0-306-47283-1
- language
- English
- LU publication?
- yes
- id
- 56deddfc-99cf-4db8-9645-a2d2ada11476 (old id 113683)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12664584&dopt=Abstract
- date added to LUP
- 2016-04-01 15:36:17
- date last changed
- 2022-02-27 07:46:52
@inbook{56deddfc-99cf-4db8-9645-a2d2ada11476, abstract = {{LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1.}}, author = {{Thodeti, Charles Kumar and Sjölander, Anita}}, booktitle = {{Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 (Advances in Experimental Medicine and Biology)}}, isbn = {{978-0-306-47283-1}}, issn = {{0065-2598}}, language = {{eng}}, pages = {{187--191}}, publisher = {{Springer}}, title = {{Leukotriene D4-induced calcium signaling in human intestinal epithelial cells.}}, url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12664584&dopt=Abstract}}, volume = {{507}}, year = {{2002}}, }