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The Lim-only protein LMO2 acts as a positive regulator of erythroid differentiation

Hansson, Anders LU ; Zetterblad, Jenny; van Duren, Cathelijne; Axelson, Håkan LU and Jönsson, Jan-Ingvar LU (2007) In Biochemical and Biophysical Research Communications 364(3). p.675-681
Abstract
LMO2, a member of the LIM-only protein family, is essential for the regulation of hematopoietic stem cells and formation of erythroid cells. It is found in a transcriptional complex comprising LMO2, TAL1, E47, GATA-1, and LDB1 which regulates erythroid genes. While TAL1 has been shown to induce erythroid differentiation, LMO2 appears to suppress fetal erythropoiesis. In addition to LMO2, the closely related LMO4 gene is expressed in hematopoietic cells, but has unknown functions. Here we demonstrate that LMO2 and LMO4 are expressed at the same level in erythroid colonies from mouse bone marrow, implying a function in erythroid differentiation. However, while LMO2 induced erythroid differentiation, LMO4 had no such effect. Interestingly,... (More)
LMO2, a member of the LIM-only protein family, is essential for the regulation of hematopoietic stem cells and formation of erythroid cells. It is found in a transcriptional complex comprising LMO2, TAL1, E47, GATA-1, and LDB1 which regulates erythroid genes. While TAL1 has been shown to induce erythroid differentiation, LMO2 appears to suppress fetal erythropoiesis. In addition to LMO2, the closely related LMO4 gene is expressed in hematopoietic cells, but has unknown functions. Here we demonstrate that LMO2 and LMO4 are expressed at the same level in erythroid colonies from mouse bone marrow, implying a function in erythroid differentiation. However, while LMO2 induced erythroid differentiation, LMO4 had no such effect. Interestingly, both LMO2 and TAL1 were able to partially suppress myeloid differentiation, implying that they activate erythroid differentiation in uncommitted bone marrow progenitors. Both LMO2 and LMO4 interacted strongly to LDB1, which was required for their localization to the nucleus. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
364
issue
3
pages
675 - 681
publisher
Elsevier
external identifiers
  • pmid:17964543
  • wos:000251030500042
  • scopus:35648972676
ISSN
1090-2104
DOI
10.1016/j.bbrc.2007.10.071
language
English
LU publication?
yes
id
3028d291-cc0f-4ec2-b8b9-b29acb5048b3 (old id 1137812)
date added to LUP
2008-08-15 14:35:02
date last changed
2017-01-01 07:49:02
@article{3028d291-cc0f-4ec2-b8b9-b29acb5048b3,
  abstract     = {LMO2, a member of the LIM-only protein family, is essential for the regulation of hematopoietic stem cells and formation of erythroid cells. It is found in a transcriptional complex comprising LMO2, TAL1, E47, GATA-1, and LDB1 which regulates erythroid genes. While TAL1 has been shown to induce erythroid differentiation, LMO2 appears to suppress fetal erythropoiesis. In addition to LMO2, the closely related LMO4 gene is expressed in hematopoietic cells, but has unknown functions. Here we demonstrate that LMO2 and LMO4 are expressed at the same level in erythroid colonies from mouse bone marrow, implying a function in erythroid differentiation. However, while LMO2 induced erythroid differentiation, LMO4 had no such effect. Interestingly, both LMO2 and TAL1 were able to partially suppress myeloid differentiation, implying that they activate erythroid differentiation in uncommitted bone marrow progenitors. Both LMO2 and LMO4 interacted strongly to LDB1, which was required for their localization to the nucleus.},
  author       = {Hansson, Anders and Zetterblad, Jenny and van Duren, Cathelijne and Axelson, Håkan and Jönsson, Jan-Ingvar},
  issn         = {1090-2104},
  language     = {eng},
  number       = {3},
  pages        = {675--681},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {The Lim-only protein LMO2 acts as a positive regulator of erythroid differentiation},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2007.10.071},
  volume       = {364},
  year         = {2007},
}