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Antibodies against Kaposi sarcoma-associated herpes virus (KSHV) complement control protein (KCP) in infected individuals

Okroj, Marcin LU ; Spiller, O Brad; Korodi, Zoltan LU ; Tedeschi, Rosamaria; Dillner, Joakim LU and Blom, Anna LU (2007) In Vaccine 25(48). p.8102-8109
Abstract
Kaposi sarcoma-associated herpesvirus (KSHV) is the most important etiopathological factor of Kaposi's sarcoma (KS) and some specific types of malignant lymphomas. One of the viral lytic genes encodes the KSHV complement control protein (KCP), which functionally mimics human complement inhibitors. Although this protein provides an advantage for evading the complement attack, it can serve as target for adaptive immune response. Herein, we identified anti-KCP IgG antibodies in patients with KS and KSHV-related lymphomas. KCP-specific antibodies were only detected in sera of those patients who had high titres of antibodies against lytic or latent KSHV antigens. Complement control protein domain 2 (CCP2) was found to be the most immunogenic... (More)
Kaposi sarcoma-associated herpesvirus (KSHV) is the most important etiopathological factor of Kaposi's sarcoma (KS) and some specific types of malignant lymphomas. One of the viral lytic genes encodes the KSHV complement control protein (KCP), which functionally mimics human complement inhibitors. Although this protein provides an advantage for evading the complement attack, it can serve as target for adaptive immune response. Herein, we identified anti-KCP IgG antibodies in patients with KS and KSHV-related lymphomas. KCP-specific antibodies were only detected in sera of those patients who had high titres of antibodies against lytic or latent KSHV antigens. Complement control protein domain 2 (CCP2) was found to be the most immunogenic part of the KCP protein. Furthermore, pre-incubation of KCP-expressing CHO cells with patient sera containing anti-KCP antibodies resulted in an increased complement deposition when incubated with human serum. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Complement, Kaposi sarcoma, HIV, Lymphoma, Antibodies
in
Vaccine
volume
25
issue
48
pages
8102 - 8109
publisher
Elsevier
external identifiers
  • pmid:17964697
  • wos:000251472600002
  • scopus:35748937347
ISSN
1873-2518
DOI
10.1016/j.vaccine.2007.09.046
language
English
LU publication?
yes
id
14a4e471-2746-459b-b6be-95f412f803cf (old id 1138127)
date added to LUP
2008-08-19 09:01:31
date last changed
2017-01-01 05:07:33
@article{14a4e471-2746-459b-b6be-95f412f803cf,
  abstract     = {Kaposi sarcoma-associated herpesvirus (KSHV) is the most important etiopathological factor of Kaposi's sarcoma (KS) and some specific types of malignant lymphomas. One of the viral lytic genes encodes the KSHV complement control protein (KCP), which functionally mimics human complement inhibitors. Although this protein provides an advantage for evading the complement attack, it can serve as target for adaptive immune response. Herein, we identified anti-KCP IgG antibodies in patients with KS and KSHV-related lymphomas. KCP-specific antibodies were only detected in sera of those patients who had high titres of antibodies against lytic or latent KSHV antigens. Complement control protein domain 2 (CCP2) was found to be the most immunogenic part of the KCP protein. Furthermore, pre-incubation of KCP-expressing CHO cells with patient sera containing anti-KCP antibodies resulted in an increased complement deposition when incubated with human serum.},
  author       = {Okroj, Marcin and Spiller, O Brad and Korodi, Zoltan and Tedeschi, Rosamaria and Dillner, Joakim and Blom, Anna},
  issn         = {1873-2518},
  keyword      = {Complement,Kaposi sarcoma,HIV,Lymphoma,Antibodies},
  language     = {eng},
  number       = {48},
  pages        = {8102--8109},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Antibodies against Kaposi sarcoma-associated herpes virus (KSHV) complement control protein (KCP) in infected individuals},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2007.09.046},
  volume       = {25},
  year         = {2007},
}