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Complete ascertainment of Parkinson disease in the Swedish Twin Registry

Wirdefeldt, Karin; Gatz, Margaret; Bakaysa, Stephanie L; Fiske, Amy; Flensburg, Måns; Petzinger, Giselle M; Widner, Håkan LU ; Lew, Mark F; Welsh, Mickie and Pedersen, Nancy L (2008) In Neurobiology of Aging 29(12). p.1765-1773
Abstract
This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD... (More)
This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Family history, Twin, Parkinson disease, Prevalence, Concordance
in
Neurobiology of Aging
volume
29
issue
12
pages
1765 - 1773
publisher
Elsevier
external identifiers
  • pmid:17532098
  • wos:000260718700001
  • scopus:53649109148
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2007.04.009
language
English
LU publication?
yes
id
8c38546d-41d2-44e3-8068-82795bfa6f88 (old id 1139570)
date added to LUP
2008-04-29 10:20:36
date last changed
2017-01-01 04:40:51
@article{8c38546d-41d2-44e3-8068-82795bfa6f88,
  abstract     = {This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD.},
  author       = {Wirdefeldt, Karin and Gatz, Margaret and Bakaysa, Stephanie L and Fiske, Amy and Flensburg, Måns and Petzinger, Giselle M and Widner, Håkan and Lew, Mark F and Welsh, Mickie and Pedersen, Nancy L},
  issn         = {1558-1497},
  keyword      = {Family history,Twin,Parkinson disease,Prevalence,Concordance},
  language     = {eng},
  number       = {12},
  pages        = {1765--1773},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Complete ascertainment of Parkinson disease in the Swedish Twin Registry},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2007.04.009},
  volume       = {29},
  year         = {2008},
}