Complete ascertainment of Parkinson disease in the Swedish Twin Registry
(2008) In Neurobiology of Aging 29(12). p.1765-1773- Abstract
- This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD... (More)
- This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1139570
- author
- Wirdefeldt, Karin ; Gatz, Margaret ; Bakaysa, Stephanie L ; Fiske, Amy ; Flensburg, Måns ; Petzinger, Giselle M ; Widner, Håkan LU ; Lew, Mark F ; Welsh, Mickie and Pedersen, Nancy L
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Family history, Twin, Parkinson disease, Prevalence, Concordance
- in
- Neurobiology of Aging
- volume
- 29
- issue
- 12
- pages
- 1765 - 1773
- publisher
- Elsevier
- external identifiers
-
- pmid:17532098
- wos:000260718700001
- scopus:53649109148
- ISSN
- 1558-1497
- DOI
- 10.1016/j.neurobiolaging.2007.04.009
- language
- English
- LU publication?
- yes
- id
- 8c38546d-41d2-44e3-8068-82795bfa6f88 (old id 1139570)
- date added to LUP
- 2016-04-01 11:56:06
- date last changed
- 2022-04-13 03:30:38
@article{8c38546d-41d2-44e3-8068-82795bfa6f88, abstract = {{This report describes the ascertainment of Parkinson disease (PD) in all individuals aged 50 years or older (49,814 individuals) from the Swedish Twin Registry. In phase one of the study, all twins were screened for PD using telephone interviews, with a response rate of 72.7%. In phase two, twins with suspected PD were re-contacted to exclude anyone from follow-up who reported parkinsonian symptoms due to diseases other than PD. In the third phase, in-person clinical evaluations were completed for twins who were still considered PD suspects after phase two and for a sample of co-twins. During the clinical evaluations, we also collected blood samples and information about a variety of environmental exposures. Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD.}}, author = {{Wirdefeldt, Karin and Gatz, Margaret and Bakaysa, Stephanie L and Fiske, Amy and Flensburg, Måns and Petzinger, Giselle M and Widner, Håkan and Lew, Mark F and Welsh, Mickie and Pedersen, Nancy L}}, issn = {{1558-1497}}, keywords = {{Family history; Twin; Parkinson disease; Prevalence; Concordance}}, language = {{eng}}, number = {{12}}, pages = {{1765--1773}}, publisher = {{Elsevier}}, series = {{Neurobiology of Aging}}, title = {{Complete ascertainment of Parkinson disease in the Swedish Twin Registry}}, url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2007.04.009}}, doi = {{10.1016/j.neurobiolaging.2007.04.009}}, volume = {{29}}, year = {{2008}}, }