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The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.

Kamp-Nielsen, Christian LU ; Öhd, John LU ; Wikström, Katarina LU ; Massoumi, Ramin LU ; Paruchuri, Sailaja LU ; Juhas, Maria LU and Sjölander, Anita LU (2003) In Advances in Experimental Medicine and Biology 525. p.201-204
Abstract
The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect... (More)
The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research
series title
Advances in Experimental Medicine and Biology
volume
525
pages
201 - 204
publisher
Springer
external identifiers
  • wos:000183072500043
  • pmid:12751768
  • scopus:0037530152
ISSN
0065-2598
ISBN
978-0-306-47763-8
DOI
10.1007/978-1-4419-9194-2_43
language
English
LU publication?
yes
id
7bd8c4c1-2b3e-4e99-82ae-e4eccde3302c (old id 113976)
date added to LUP
2016-04-01 15:45:17
date last changed
2021-07-08 11:18:49
@inbook{7bd8c4c1-2b3e-4e99-82ae-e4eccde3302c,
  abstract     = {The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.},
  author       = {Kamp-Nielsen, Christian and Öhd, John and Wikström, Katarina and Massoumi, Ramin and Paruchuri, Sailaja and Juhas, Maria and Sjölander, Anita},
  booktitle    = {Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research},
  isbn         = {978-0-306-47763-8},
  issn         = {0065-2598},
  language     = {eng},
  pages        = {201--204},
  publisher    = {Springer},
  series       = {Advances in Experimental Medicine and Biology},
  title        = {The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.},
  url          = {http://dx.doi.org/10.1007/978-1-4419-9194-2_43},
  doi          = {10.1007/978-1-4419-9194-2_43},
  volume       = {525},
  year         = {2003},
}