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The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.

Kamp-Nielsen, Christian LU ; Öhd, John LU ; Wikström, Katarina LU ; Massoumi, Ramin LU ; Paruchuri, Sailaja LU ; Juhas, Maria LU and Sjölander, Anita LU (2003) In Advances in Experimental Medicine and Biology 525. p.201-204
Abstract
The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect... (More)
The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research
series title
Advances in Experimental Medicine and Biology
volume
525
pages
201 - 204
publisher
Springer
external identifiers
  • wos:000183072500043
  • pmid:12751768
  • scopus:0037530152
ISSN
0065-2598
ISBN
978-0-306-47763-8
DOI
10.1007/978-1-4419-9194-2_43
language
English
LU publication?
yes
id
7bd8c4c1-2b3e-4e99-82ae-e4eccde3302c (old id 113976)
date added to LUP
2016-04-01 15:45:17
date last changed
2022-01-28 06:54:55
@inbook{7bd8c4c1-2b3e-4e99-82ae-e4eccde3302c,
  abstract     = {{The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.}},
  author       = {{Kamp-Nielsen, Christian and Öhd, John and Wikström, Katarina and Massoumi, Ramin and Paruchuri, Sailaja and Juhas, Maria and Sjölander, Anita}},
  booktitle    = {{Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research}},
  isbn         = {{978-0-306-47763-8}},
  issn         = {{0065-2598}},
  language     = {{eng}},
  pages        = {{201--204}},
  publisher    = {{Springer}},
  series       = {{Advances in Experimental Medicine and Biology}},
  title        = {{The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.}},
  url          = {{http://dx.doi.org/10.1007/978-1-4419-9194-2_43}},
  doi          = {{10.1007/978-1-4419-9194-2_43}},
  volume       = {{525}},
  year         = {{2003}},
}