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Age-related Effects of the Probiotic Bacterium Lactobacillus plantarum 299v on Gastrointestinal Function in Suckling Rats

Fåk, Frida LU ; Ahrné, Siv LU ; Linderoth, Ann LU ; Molin, Göran LU ; Jeppsson, Bengt LU and Weström, Björn LU (2008) In Digestive Diseases and Sciences 53(664-671). p.664-671
Abstract
The effect of a probiotic bacterium on gut function was studied in neonatal animals by using a model with suckling rats. Lactobacillus plantarum 299v (Lp299v) or saline (controls) was fed (3.0 x 10(6) CFU/g b.wt per day) for one week to rats aged either 3, 7 or 14 days, after which bacterial colonization, gut growth, and functional parameters were analyzed. In rats fed with Lp299v from 3 to 10 days of age, an increase in ceacal lactobacilli was correlated with reduced intestinal macromolecular permeability and increased mucosal protein compared to age-matched controls. Pups treated from 7 to 14 days of age showed a decrease in pancreas weight and protein content, whereas pups treated from 14 to 21 days of age showed little effect of the... (More)
The effect of a probiotic bacterium on gut function was studied in neonatal animals by using a model with suckling rats. Lactobacillus plantarum 299v (Lp299v) or saline (controls) was fed (3.0 x 10(6) CFU/g b.wt per day) for one week to rats aged either 3, 7 or 14 days, after which bacterial colonization, gut growth, and functional parameters were analyzed. In rats fed with Lp299v from 3 to 10 days of age, an increase in ceacal lactobacilli was correlated with reduced intestinal macromolecular permeability and increased mucosal protein compared to age-matched controls. Pups treated from 7 to 14 days of age showed a decrease in pancreas weight and protein content, whereas pups treated from 14 to 21 days of age showed little effect of the Lp299v treatment. The results indicated that the bacterial exposure affected the gut function, where the effects were age-related and the youngest rats appeared most sensitive. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Digestive Diseases and Sciences
volume
53
issue
664-671
pages
664 - 671
publisher
Springer
external identifiers
  • wos:000253570700010
  • pmid:17616816
  • scopus:39849090607
ISSN
1573-2568
DOI
10.1007/s10620-007-9906-1
language
English
LU publication?
yes
id
2a608ac3-bbe4-47dc-bfcc-e1e0a6bc7946 (old id 1141887)
date added to LUP
2008-08-05 16:00:38
date last changed
2017-08-06 03:51:18
@article{2a608ac3-bbe4-47dc-bfcc-e1e0a6bc7946,
  abstract     = {The effect of a probiotic bacterium on gut function was studied in neonatal animals by using a model with suckling rats. Lactobacillus plantarum 299v (Lp299v) or saline (controls) was fed (3.0 x 10(6) CFU/g b.wt per day) for one week to rats aged either 3, 7 or 14 days, after which bacterial colonization, gut growth, and functional parameters were analyzed. In rats fed with Lp299v from 3 to 10 days of age, an increase in ceacal lactobacilli was correlated with reduced intestinal macromolecular permeability and increased mucosal protein compared to age-matched controls. Pups treated from 7 to 14 days of age showed a decrease in pancreas weight and protein content, whereas pups treated from 14 to 21 days of age showed little effect of the Lp299v treatment. The results indicated that the bacterial exposure affected the gut function, where the effects were age-related and the youngest rats appeared most sensitive.},
  author       = {Fåk, Frida and Ahrné, Siv and Linderoth, Ann and Molin, Göran and Jeppsson, Bengt and Weström, Björn},
  issn         = {1573-2568},
  language     = {eng},
  number       = {664-671},
  pages        = {664--671},
  publisher    = {Springer},
  series       = {Digestive Diseases and Sciences},
  title        = {Age-related Effects of the Probiotic Bacterium Lactobacillus plantarum 299v on Gastrointestinal Function in Suckling Rats},
  url          = {http://dx.doi.org/10.1007/s10620-007-9906-1},
  volume       = {53},
  year         = {2008},
}