Age-related Effects of the Probiotic Bacterium Lactobacillus plantarum 299v on Gastrointestinal Function in Suckling Rats
(2008) In Digestive Diseases and Sciences 53(664-671). p.664-671- Abstract
- The effect of a probiotic bacterium on gut function was studied in neonatal animals by using a model with suckling rats. Lactobacillus plantarum 299v (Lp299v) or saline (controls) was fed (3.0 x 10(6) CFU/g b.wt per day) for one week to rats aged either 3, 7 or 14 days, after which bacterial colonization, gut growth, and functional parameters were analyzed. In rats fed with Lp299v from 3 to 10 days of age, an increase in ceacal lactobacilli was correlated with reduced intestinal macromolecular permeability and increased mucosal protein compared to age-matched controls. Pups treated from 7 to 14 days of age showed a decrease in pancreas weight and protein content, whereas pups treated from 14 to 21 days of age showed little effect of the... (More)
- The effect of a probiotic bacterium on gut function was studied in neonatal animals by using a model with suckling rats. Lactobacillus plantarum 299v (Lp299v) or saline (controls) was fed (3.0 x 10(6) CFU/g b.wt per day) for one week to rats aged either 3, 7 or 14 days, after which bacterial colonization, gut growth, and functional parameters were analyzed. In rats fed with Lp299v from 3 to 10 days of age, an increase in ceacal lactobacilli was correlated with reduced intestinal macromolecular permeability and increased mucosal protein compared to age-matched controls. Pups treated from 7 to 14 days of age showed a decrease in pancreas weight and protein content, whereas pups treated from 14 to 21 days of age showed little effect of the Lp299v treatment. The results indicated that the bacterial exposure affected the gut function, where the effects were age-related and the youngest rats appeared most sensitive. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1141887
- author
- Fåk, Frida
LU
; Ahrné, Siv LU ; Linderoth, Ann LU ; Molin, Göran LU ; Jeppsson, Bengt LU and Weström, Björn LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Digestive Diseases and Sciences
- volume
- 53
- issue
- 664-671
- pages
- 664 - 671
- publisher
- Springer
- external identifiers
-
- wos:000253570700010
- pmid:17616816
- scopus:39849090607
- pmid:17616816
- ISSN
- 1573-2568
- DOI
- 10.1007/s10620-007-9906-1
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300), Functional Zoology (432112239), Surgery Research Unit (013242220), Department of Biology (000016100)
- id
- 2a608ac3-bbe4-47dc-bfcc-e1e0a6bc7946 (old id 1141887)
- date added to LUP
- 2016-04-01 12:35:53
- date last changed
- 2024-01-09 02:09:05
@article{2a608ac3-bbe4-47dc-bfcc-e1e0a6bc7946, abstract = {{The effect of a probiotic bacterium on gut function was studied in neonatal animals by using a model with suckling rats. Lactobacillus plantarum 299v (Lp299v) or saline (controls) was fed (3.0 x 10(6) CFU/g b.wt per day) for one week to rats aged either 3, 7 or 14 days, after which bacterial colonization, gut growth, and functional parameters were analyzed. In rats fed with Lp299v from 3 to 10 days of age, an increase in ceacal lactobacilli was correlated with reduced intestinal macromolecular permeability and increased mucosal protein compared to age-matched controls. Pups treated from 7 to 14 days of age showed a decrease in pancreas weight and protein content, whereas pups treated from 14 to 21 days of age showed little effect of the Lp299v treatment. The results indicated that the bacterial exposure affected the gut function, where the effects were age-related and the youngest rats appeared most sensitive.}}, author = {{Fåk, Frida and Ahrné, Siv and Linderoth, Ann and Molin, Göran and Jeppsson, Bengt and Weström, Björn}}, issn = {{1573-2568}}, language = {{eng}}, number = {{664-671}}, pages = {{664--671}}, publisher = {{Springer}}, series = {{Digestive Diseases and Sciences}}, title = {{Age-related Effects of the Probiotic Bacterium Lactobacillus plantarum 299v on Gastrointestinal Function in Suckling Rats}}, url = {{http://dx.doi.org/10.1007/s10620-007-9906-1}}, doi = {{10.1007/s10620-007-9906-1}}, volume = {{53}}, year = {{2008}}, }