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The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism

Ylonen, SK; Salminen, I; Lyssenko, Valeriya LU ; Virtanen, SM; Groop, Leif LU ; Aro, A and Saloranta, C (2008) In European Journal of Clinical Nutrition 62(12). p.1432-1439
Abstract
Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis.Subjects/Methods:The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma... (More)
Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis.Subjects/Methods:The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma variables with insulin resistance and fasting and 2-h glucose and free fatty acid concentrations were analysed with multiple linear regression analysis.Results:In men, there was a significant interaction between PPARG polymorphism and plasma docosahexaenoic acid on fasting free fatty acid concentration (P=0.036), and genotype-stratified models showed an inverse association in Pro homozygotes only (P=0.028). In women, the proportion of plasma eicosapentaenoic acid was higher in Ala-allele carriers compared to Pro homozygotes (1.67 vs 1.44% respectively, P=0.006). A significant interaction between PPARG polymorphism and fish intake on 2-h glucose was found in women (P=0.021), and genotype-stratified models suggested an inverse association in Ala-allele carriers only (P=0.039).Conclusions:The findings suggest that PPARG polymorphism might affect the plasma proportion of eicosapentaenoic acid and modulate the associations of fish intake and marine n-3 fatty acids with glucose metabolism and fasting free fatty acids.European Journal of Clinical Nutrition advance online publication, 15 August 2007; doi:10.1038/sj.ejcn.1602882. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glucose concentrations, concentrations, FFA, insulin resistance, polymorphism, PPAR-gamma 2 Pro12Ala, marine n-3 fatty acids, fish intake
in
European Journal of Clinical Nutrition
volume
62
issue
12
pages
1432 - 1439
publisher
Nature Publishing Group
external identifiers
  • pmid:17700648
  • wos:000261330800011
  • scopus:57449103940
ISSN
1476-5640
DOI
10.1038/sj.ejcn.1602882
language
English
LU publication?
yes
id
d4362153-200e-4b86-8717-6e4206c20db0 (old id 1141911)
date added to LUP
2008-08-08 13:54:00
date last changed
2017-01-01 06:14:33
@article{d4362153-200e-4b86-8717-6e4206c20db0,
  abstract     = {Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis.Subjects/Methods:The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma variables with insulin resistance and fasting and 2-h glucose and free fatty acid concentrations were analysed with multiple linear regression analysis.Results:In men, there was a significant interaction between PPARG polymorphism and plasma docosahexaenoic acid on fasting free fatty acid concentration (P=0.036), and genotype-stratified models showed an inverse association in Pro homozygotes only (P=0.028). In women, the proportion of plasma eicosapentaenoic acid was higher in Ala-allele carriers compared to Pro homozygotes (1.67 vs 1.44% respectively, P=0.006). A significant interaction between PPARG polymorphism and fish intake on 2-h glucose was found in women (P=0.021), and genotype-stratified models suggested an inverse association in Ala-allele carriers only (P=0.039).Conclusions:The findings suggest that PPARG polymorphism might affect the plasma proportion of eicosapentaenoic acid and modulate the associations of fish intake and marine n-3 fatty acids with glucose metabolism and fasting free fatty acids.European Journal of Clinical Nutrition advance online publication, 15 August 2007; doi:10.1038/sj.ejcn.1602882.},
  author       = {Ylonen, SK and Salminen, I and Lyssenko, Valeriya and Virtanen, SM and Groop, Leif and Aro, A and Saloranta, C},
  issn         = {1476-5640},
  keyword      = {glucose concentrations,concentrations,FFA,insulin resistance,polymorphism,PPAR-gamma 2 Pro12Ala,marine n-3 fatty acids,fish intake},
  language     = {eng},
  number       = {12},
  pages        = {1432--1439},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1602882},
  volume       = {62},
  year         = {2008},
}