The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism
(2008) In European Journal of Clinical Nutrition 62(12). p.1432-1439- Abstract
- Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis.Subjects/Methods:The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma... (More)
- Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis.Subjects/Methods:The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma variables with insulin resistance and fasting and 2-h glucose and free fatty acid concentrations were analysed with multiple linear regression analysis.Results:In men, there was a significant interaction between PPARG polymorphism and plasma docosahexaenoic acid on fasting free fatty acid concentration (P=0.036), and genotype-stratified models showed an inverse association in Pro homozygotes only (P=0.028). In women, the proportion of plasma eicosapentaenoic acid was higher in Ala-allele carriers compared to Pro homozygotes (1.67 vs 1.44% respectively, P=0.006). A significant interaction between PPARG polymorphism and fish intake on 2-h glucose was found in women (P=0.021), and genotype-stratified models suggested an inverse association in Ala-allele carriers only (P=0.039).Conclusions:The findings suggest that PPARG polymorphism might affect the plasma proportion of eicosapentaenoic acid and modulate the associations of fish intake and marine n-3 fatty acids with glucose metabolism and fasting free fatty acids.European Journal of Clinical Nutrition advance online publication, 15 August 2007; doi:10.1038/sj.ejcn.1602882. (Less)
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https://lup.lub.lu.se/record/1141911
- author
- Ylonen, SK ; Salminen, I ; Lyssenko, Valeriya LU ; Virtanen, SM ; Groop, Leif LU ; Aro, A and Saloranta, C
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glucose concentrations, concentrations, FFA, insulin resistance, polymorphism, PPAR-gamma 2 Pro12Ala, marine n-3 fatty acids, fish intake
- in
- European Journal of Clinical Nutrition
- volume
- 62
- issue
- 12
- pages
- 1432 - 1439
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:17700648
- wos:000261330800011
- scopus:57449103940
- pmid:17700648
- ISSN
- 1476-5640
- DOI
- 10.1038/sj.ejcn.1602882
- language
- English
- LU publication?
- yes
- id
- d4362153-200e-4b86-8717-6e4206c20db0 (old id 1141911)
- date added to LUP
- 2016-04-01 14:25:51
- date last changed
- 2024-01-10 03:38:29
@article{d4362153-200e-4b86-8717-6e4206c20db0,
abstract = {{Background/Objectives:Data on associations between marine n-3 fatty acids and glucose metabolism are inconsistent. Therefore, we explored effects of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor (PPAR)-gamma2 gene on associations of fish intake and dietary and plasma eicosapentaenoic and docosahexaenoic acid with glucose metabolism. The design comprises of the cross-sectional analysis.Subjects/Methods:The Pro12Ala variant in the PPAR-gamma2 (PPARG) gene was genotyped in 571 non-diabetic relatives of subjects with type II diabetes. The dietary intake was measured by a 3-day food record, and the plasma cholesterol ester fatty acid composition was analysed with gas chromatography. Associations of dietary and plasma variables with insulin resistance and fasting and 2-h glucose and free fatty acid concentrations were analysed with multiple linear regression analysis.Results:In men, there was a significant interaction between PPARG polymorphism and plasma docosahexaenoic acid on fasting free fatty acid concentration (P=0.036), and genotype-stratified models showed an inverse association in Pro homozygotes only (P=0.028). In women, the proportion of plasma eicosapentaenoic acid was higher in Ala-allele carriers compared to Pro homozygotes (1.67 vs 1.44% respectively, P=0.006). A significant interaction between PPARG polymorphism and fish intake on 2-h glucose was found in women (P=0.021), and genotype-stratified models suggested an inverse association in Ala-allele carriers only (P=0.039).Conclusions:The findings suggest that PPARG polymorphism might affect the plasma proportion of eicosapentaenoic acid and modulate the associations of fish intake and marine n-3 fatty acids with glucose metabolism and fasting free fatty acids.European Journal of Clinical Nutrition advance online publication, 15 August 2007; doi:10.1038/sj.ejcn.1602882.}},
author = {{Ylonen, SK and Salminen, I and Lyssenko, Valeriya and Virtanen, SM and Groop, Leif and Aro, A and Saloranta, C}},
issn = {{1476-5640}},
keywords = {{glucose concentrations; concentrations; FFA; insulin resistance; polymorphism; PPAR-gamma 2 Pro12Ala; marine n-3 fatty acids; fish intake}},
language = {{eng}},
number = {{12}},
pages = {{1432--1439}},
publisher = {{Nature Publishing Group}},
series = {{European Journal of Clinical Nutrition}},
title = {{The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism}},
url = {{http://dx.doi.org/10.1038/sj.ejcn.1602882}},
doi = {{10.1038/sj.ejcn.1602882}},
volume = {{62}},
year = {{2008}},
}