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Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort

Urowitz, M B; Gladman, D; Ibanez, D; Fortin, P; Sanchez-Guerrero, J; Bae, S; Clarke, A; Bernatsky, S; Gordon, C and Hanly, J, et al. (2007) In Lupus 16(9). p.731-735
Abstract
Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and... (More)
Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE. (Less)
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publication status
published
subject
in
Lupus
volume
16
issue
9
pages
731 - 735
publisher
SAGE Publications Ltd
external identifiers
  • pmid:17728367
  • scopus:34948827357
ISSN
0961-2033
DOI
10.1177/0961203307081113
language
English
LU publication?
yes
id
6f53fca0-55e9-4808-b229-cfbe4f6bf436 (old id 1142696)
date added to LUP
2008-08-01 12:27:14
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2017-11-19 03:33:23
@article{6f53fca0-55e9-4808-b229-cfbe4f6bf436,
  abstract     = {Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.},
  author       = {Urowitz, M B and Gladman, D and Ibanez, D and Fortin, P and Sanchez-Guerrero, J and Bae, S and Clarke, A and Bernatsky, S and Gordon, C and Hanly, J and Wallace, D and Isenberg, D and Ginzler, E and Merrill, J and Alarcon, G and Steinsson, K and Petri, M and Dooley, M A and Bruce, I and Manzi, S and Khamashta, M and Ramsey-Goldman, R and Zoma, A and Sturfelt, Gunnar and Nived, Ola and Maddison, P and Font, J and van Vollenhoven, R and Aranow, C and Kalunian, K and Stoll, T and Buyon, J},
  issn         = {0961-2033},
  language     = {eng},
  number       = {9},
  pages        = {731--735},
  publisher    = {SAGE Publications Ltd},
  series       = {Lupus},
  title        = {Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort},
  url          = {http://dx.doi.org/10.1177/0961203307081113},
  volume       = {16},
  year         = {2007},
}