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Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort

Urowitz, M B ; Gladman, D ; Ibanez, D ; Fortin, P ; Sanchez-Guerrero, J ; Bae, S ; Clarke, A ; Bernatsky, S ; Gordon, C and Hanly, J , et al. (2007) In Lupus 16(9). p.731-735
Abstract
Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and... (More)
Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lupus
volume
16
issue
9
pages
731 - 735
publisher
SAGE Publications
external identifiers
  • pmid:17728367
  • scopus:34948827357
ISSN
0961-2033
DOI
10.1177/0961203307081113
language
English
LU publication?
yes
id
6f53fca0-55e9-4808-b229-cfbe4f6bf436 (old id 1142696)
date added to LUP
2016-04-01 12:08:31
date last changed
2022-04-29 01:12:30
@article{6f53fca0-55e9-4808-b229-cfbe4f6bf436,
  abstract     = {{Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.}},
  author       = {{Urowitz, M B and Gladman, D and Ibanez, D and Fortin, P and Sanchez-Guerrero, J and Bae, S and Clarke, A and Bernatsky, S and Gordon, C and Hanly, J and Wallace, D and Isenberg, D and Ginzler, E and Merrill, J and Alarcon, G and Steinsson, K and Petri, M and Dooley, M A and Bruce, I and Manzi, S and Khamashta, M and Ramsey-Goldman, R and Zoma, A and Sturfelt, Gunnar and Nived, Ola and Maddison, P and Font, J and van Vollenhoven, R and Aranow, C and Kalunian, K and Stoll, T and Buyon, J}},
  issn         = {{0961-2033}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{731--735}},
  publisher    = {{SAGE Publications}},
  series       = {{Lupus}},
  title        = {{Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort}},
  url          = {{http://dx.doi.org/10.1177/0961203307081113}},
  doi          = {{10.1177/0961203307081113}},
  volume       = {{16}},
  year         = {{2007}},
}