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Effects of restricted diffusion in a biological phantom: a q-space diffusion MRI study of asparagus stems at a 3T clinical scanner

Lätt, Jimmy LU ; Nilsson, Markus LU ; Rydhög, Anna; Wirestam, Ronnie LU ; Ståhlberg, Freddy LU and Brockstedt, Sara LU (2007) In Magma 20(4). p.213-222
Abstract
Introduction The aim of this work was to study the effects of restricted diffusion in a biological phantom consisting of green asparagus stems using q-space MRI at a clinical scanner.

Method Measurements of the full width at half maximum (FWHM) of the displacement distribution were performed with varied diffusion time (T d). The accuracy of the measurements was investigated with respect to the degree of violation of the short gradient pulse (SGP) condition, partial volume effects and a FWHM-based tensor model.

Results The measurements showed a reasonably constant FWHM perpendicular to the capillaries in the vascular bundles and an increased FWHM parallel with the bundles when the T d was increased. A 15% decrease in FWHM... (More)
Introduction The aim of this work was to study the effects of restricted diffusion in a biological phantom consisting of green asparagus stems using q-space MRI at a clinical scanner.

Method Measurements of the full width at half maximum (FWHM) of the displacement distribution were performed with varied diffusion time (T d). The accuracy of the measurements was investigated with respect to the degree of violation of the short gradient pulse (SGP) condition, partial volume effects and a FWHM-based tensor model.

Results The measurements showed a reasonably constant FWHM perpendicular to the capillaries in the vascular bundles and an increased FWHM parallel with the bundles when the T d was increased. A 15% decrease in FWHM perpendicular to the bundles was observed when the diffusion encoding duration was prolonged from 24 to 74 ms, owing to the violation of the SGP condition. For a population of different confinement sizes, simulations indicated that the FWHM reflects the smaller sizes rather then the mean size of the confinements.

Conclusion A new method allowing tensor analysis of FWHM was derived and yielded accurate results. In conclusion, we found it possible to measure the effects of restricted diffusion with q-space MRI using a clinical MRI scanner. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magma
volume
20
issue
4
pages
213 - 222
publisher
Springer
external identifiers
  • wos:000250920400007
  • scopus:36248976546
ISSN
1352-8661
DOI
10.1007/s10334-007-0085-z
language
English
LU publication?
yes
id
8fd0ceef-6d6b-41e4-b11c-bb5f216b71ce (old id 1142954)
date added to LUP
2008-07-31 12:55:23
date last changed
2017-07-30 04:38:32
@article{8fd0ceef-6d6b-41e4-b11c-bb5f216b71ce,
  abstract     = {Introduction The aim of this work was to study the effects of restricted diffusion in a biological phantom consisting of green asparagus stems using q-space MRI at a clinical scanner.<br/><br>
Method Measurements of the full width at half maximum (FWHM) of the displacement distribution were performed with varied diffusion time (T d). The accuracy of the measurements was investigated with respect to the degree of violation of the short gradient pulse (SGP) condition, partial volume effects and a FWHM-based tensor model.<br/><br>
Results The measurements showed a reasonably constant FWHM perpendicular to the capillaries in the vascular bundles and an increased FWHM parallel with the bundles when the T d was increased. A 15% decrease in FWHM perpendicular to the bundles was observed when the diffusion encoding duration was prolonged from 24 to 74 ms, owing to the violation of the SGP condition. For a population of different confinement sizes, simulations indicated that the FWHM reflects the smaller sizes rather then the mean size of the confinements.<br/><br>
Conclusion A new method allowing tensor analysis of FWHM was derived and yielded accurate results. In conclusion, we found it possible to measure the effects of restricted diffusion with q-space MRI using a clinical MRI scanner.},
  author       = {Lätt, Jimmy and Nilsson, Markus and Rydhög, Anna and Wirestam, Ronnie and Ståhlberg, Freddy and Brockstedt, Sara},
  issn         = {1352-8661},
  language     = {eng},
  number       = {4},
  pages        = {213--222},
  publisher    = {Springer},
  series       = {Magma},
  title        = {Effects of restricted diffusion in a biological phantom: a q-space diffusion MRI study of asparagus stems at a 3T clinical scanner},
  url          = {http://dx.doi.org/10.1007/s10334-007-0085-z},
  volume       = {20},
  year         = {2007},
}