Advanced

The role of MRI of the brain and spinal cord, and CSF examination for the diagnosis of primary progressive multiple sclerosis

Nilsson, Petra LU ; Sandberg Wollheim, Magnhild LU ; Norrving, Bo LU and Larsson, E-M (2007) In European Journal of Neurology 14(11). p.1292-1295
Abstract
The clinical applicability of the revised McDonald diagnostic criteria of primary progressive multiple sclerosis (PPMS) was assessed in 17 patients with a longstanding PPMS diagnosis (mean 15 years). All patients were re-evaluated with clinical examinations, magnetic resonance imaging (MRI) of the brain and the spinal cord, extensive laboratory tests, and 12 patients underwent cerebrospinal fluid (CSF) examination. No diagnosis more likely than PPMS was disclosed. All patients had brain and spinal cord lesions on MRI. In 15 patients the brain lesions and in 14 the spinal cord lesions fulfilled the revised McDonald criteria for positive scans. No contrast-enhancing lesion was observed despite administration of triple doses of gadolinium. In... (More)
The clinical applicability of the revised McDonald diagnostic criteria of primary progressive multiple sclerosis (PPMS) was assessed in 17 patients with a longstanding PPMS diagnosis (mean 15 years). All patients were re-evaluated with clinical examinations, magnetic resonance imaging (MRI) of the brain and the spinal cord, extensive laboratory tests, and 12 patients underwent cerebrospinal fluid (CSF) examination. No diagnosis more likely than PPMS was disclosed. All patients had brain and spinal cord lesions on MRI. In 15 patients the brain lesions and in 14 the spinal cord lesions fulfilled the revised McDonald criteria for positive scans. No contrast-enhancing lesion was observed despite administration of triple doses of gadolinium. In total, 12 patients fulfilled the revised McDonald MRI criteria for PPMS. Of the remaining five patients who incompletely fulfilled the revised MRI criteria, all had CSF findings supporting the diagnosis PPMS. Thus, CSF analysis was required in addition to MRI in about one-third of the patients to establish the diagnosis of PPMS. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Neurology
volume
14
issue
11
pages
1292 - 1295
publisher
Wiley-Blackwell
external identifiers
  • pmid:17764461
  • wos:000250959200015
  • scopus:35448993352
ISSN
1351-5101
DOI
10.1111/j.1468-1331.2007.01932.x
language
English
LU publication?
yes
id
c5b1883f-bd2a-4f6e-bd2c-ca110e8d3445 (old id 1142961)
date added to LUP
2008-07-31 13:01:13
date last changed
2017-01-01 04:56:36
@article{c5b1883f-bd2a-4f6e-bd2c-ca110e8d3445,
  abstract     = {The clinical applicability of the revised McDonald diagnostic criteria of primary progressive multiple sclerosis (PPMS) was assessed in 17 patients with a longstanding PPMS diagnosis (mean 15 years). All patients were re-evaluated with clinical examinations, magnetic resonance imaging (MRI) of the brain and the spinal cord, extensive laboratory tests, and 12 patients underwent cerebrospinal fluid (CSF) examination. No diagnosis more likely than PPMS was disclosed. All patients had brain and spinal cord lesions on MRI. In 15 patients the brain lesions and in 14 the spinal cord lesions fulfilled the revised McDonald criteria for positive scans. No contrast-enhancing lesion was observed despite administration of triple doses of gadolinium. In total, 12 patients fulfilled the revised McDonald MRI criteria for PPMS. Of the remaining five patients who incompletely fulfilled the revised MRI criteria, all had CSF findings supporting the diagnosis PPMS. Thus, CSF analysis was required in addition to MRI in about one-third of the patients to establish the diagnosis of PPMS.},
  author       = {Nilsson, Petra and Sandberg Wollheim, Magnhild and Norrving, Bo and Larsson, E-M},
  issn         = {1351-5101},
  language     = {eng},
  number       = {11},
  pages        = {1292--1295},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neurology},
  title        = {The role of MRI of the brain and spinal cord, and CSF examination for the diagnosis of primary progressive multiple sclerosis},
  url          = {http://dx.doi.org/10.1111/j.1468-1331.2007.01932.x},
  volume       = {14},
  year         = {2007},
}