Advanced

Group B streptococcal carriage in Sweden: a national study on risk factors for mother and infant colonisation

Håkansson, Stellan; Axemo, Pia; Bremme, Katarina; Bryngelsson, Anna-Lena; Wallin, Marie Carlsson; Ekström, Carl-Magnus; Granlund, Margareta; Jacobsson, Bo; Källén, Karin LU and Spetz, Eva, et al. (2008) In Acta Obstetricia et Gynecologica Scandinavica 87(1). p.50-58
Abstract
Background. To study group B streptococcus (GBS) colonisation in parturients and infants in relation to obstetric outcome and to define serotypes and antibiotic resistance in GBS isolates acquired. Methods. A population-based, national cohort of parturients and their infants was investigated. During 1 calendar week in 2005 all women giving birth (n=1,754) were requested to participate in the study. Results. A total of 1,569 mother/infant pairs with obstetric and bacteriological data were obtained. Maternal carriage rate was 25.4% (95% confidence interval (CI): 23.3-27.6). In GBS-positive mothers with vaginal delivery and no intrapartum antibiotics, the infant colonisation rate was 68%. Some 30% of infants were colonised after acute... (More)
Background. To study group B streptococcus (GBS) colonisation in parturients and infants in relation to obstetric outcome and to define serotypes and antibiotic resistance in GBS isolates acquired. Methods. A population-based, national cohort of parturients and their infants was investigated. During 1 calendar week in 2005 all women giving birth (n=1,754) were requested to participate in the study. Results. A total of 1,569 mother/infant pairs with obstetric and bacteriological data were obtained. Maternal carriage rate was 25.4% (95% confidence interval (CI): 23.3-27.6). In GBS-positive mothers with vaginal delivery and no intrapartum antibiotics, the infant colonisation rate was 68%. Some 30% of infants were colonised after acute caesarean section, and 0% were colonised after an elective procedure. Duration of transport of maternal recto/vaginal swabs of more than 1 day impeded culture sensitivity. Infant mMales were more frequently colonised than females (76.9 versus 59.8%, odds ratio (OR): 2.16; 95% CI: 1.27-3.70), as were infants born after rupture of membranes >/=24 h (p =0.039). Gestational age, birth weight and duration of labor did not significantly influence infant colonisation. Some 30% of parturients with at least one risk factor for neonatal disease received intrapartum antibiotics. The most common GBS serotypes were type III and V. Some 5% of the isolates were resistant to clindamycin and erythromycin, respectively. Conclusions. Maternal GBS prevalence and infant transfer rate were high in Sweden. Males were more frequently colonised than females. The sensitivity of maternal cultures decreased with the duration of sample transport. Clindamycin resistance was scarce. The use of intrapartum antibiotics was limited in parturients with obstetric risk factors for early onset group B streptococcal disease. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibiotic resistance, colonisation, newborn, Group B streptococcus, delivery
in
Acta Obstetricia et Gynecologica Scandinavica
volume
87
issue
1
pages
50 - 58
publisher
Wiley-Blackwell
external identifiers
  • pmid:18158627
  • wos:000252308900010
  • scopus:37549040618
ISSN
1600-0412
DOI
10.1080/00016340701802888
language
English
LU publication?
yes
id
d66a4410-0346-4850-96f9-b8a28639b76d (old id 1144219)
date added to LUP
2008-08-15 09:19:29
date last changed
2017-06-11 04:19:03
@article{d66a4410-0346-4850-96f9-b8a28639b76d,
  abstract     = {Background. To study group B streptococcus (GBS) colonisation in parturients and infants in relation to obstetric outcome and to define serotypes and antibiotic resistance in GBS isolates acquired. Methods. A population-based, national cohort of parturients and their infants was investigated. During 1 calendar week in 2005 all women giving birth (n=1,754) were requested to participate in the study. Results. A total of 1,569 mother/infant pairs with obstetric and bacteriological data were obtained. Maternal carriage rate was 25.4% (95% confidence interval (CI): 23.3-27.6). In GBS-positive mothers with vaginal delivery and no intrapartum antibiotics, the infant colonisation rate was 68%. Some 30% of infants were colonised after acute caesarean section, and 0% were colonised after an elective procedure. Duration of transport of maternal recto/vaginal swabs of more than 1 day impeded culture sensitivity. Infant mMales were more frequently colonised than females (76.9 versus 59.8%, odds ratio (OR): 2.16; 95% CI: 1.27-3.70), as were infants born after rupture of membranes >/=24 h (p =0.039). Gestational age, birth weight and duration of labor did not significantly influence infant colonisation. Some 30% of parturients with at least one risk factor for neonatal disease received intrapartum antibiotics. The most common GBS serotypes were type III and V. Some 5% of the isolates were resistant to clindamycin and erythromycin, respectively. Conclusions. Maternal GBS prevalence and infant transfer rate were high in Sweden. Males were more frequently colonised than females. The sensitivity of maternal cultures decreased with the duration of sample transport. Clindamycin resistance was scarce. The use of intrapartum antibiotics was limited in parturients with obstetric risk factors for early onset group B streptococcal disease.},
  author       = {Håkansson, Stellan and Axemo, Pia and Bremme, Katarina and Bryngelsson, Anna-Lena and Wallin, Marie Carlsson and Ekström, Carl-Magnus and Granlund, Margareta and Jacobsson, Bo and Källén, Karin and Spetz, Eva and Tessin, Ingemar and Swedish Working Group for the Prevention of Perinatal Group B Streptococcal Infections, and},
  issn         = {1600-0412},
  keyword      = {antibiotic resistance,colonisation,newborn,Group B streptococcus,delivery},
  language     = {eng},
  number       = {1},
  pages        = {50--58},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Group B streptococcal carriage in Sweden: a national study on risk factors for mother and infant colonisation},
  url          = {http://dx.doi.org/10.1080/00016340701802888},
  volume       = {87},
  year         = {2008},
}