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Variation in the bone morphogenetic protein-2 gene: effects on fat and lean body mass in young and elderly women.

McGuigan, Fiona LU ; Larzenius, Emma LU ; Callréus, Mattias LU ; Gerdhem, Paul LU ; Luthman, Holger LU and Åkesson, Kristina LU (2008) In European Journal of Endocrinology 158(5). p.661-668
Abstract
OBJECTIVE: Bone morphogenetic protein-2 (BMP2) plays a critical role in osteoblastogenesis and adipogenesis from osteoprogenitor cells. The balance between osteogenic and adipogenic effects is influenced by BMP2 concentration, transcription factors and age. BMP2 single nucleotide polymorphisms (SNPs) may contribute to osteoporosis risk, but the relationship between adiposity and body composition has not been explored. We investigated the relationship between BMP2 polymorphisms and body composition in young and elderly women. DESIGN: Population-based association study. METHODS: Four BMP2 SNPs studied. Total body fat and lean mass measured by DEXA in two cohorts: 'PEAK-25' women aged 25 (+/-0.00) (n=993) and osteoporosis prospective risk... (More)
OBJECTIVE: Bone morphogenetic protein-2 (BMP2) plays a critical role in osteoblastogenesis and adipogenesis from osteoprogenitor cells. The balance between osteogenic and adipogenic effects is influenced by BMP2 concentration, transcription factors and age. BMP2 single nucleotide polymorphisms (SNPs) may contribute to osteoporosis risk, but the relationship between adiposity and body composition has not been explored. We investigated the relationship between BMP2 polymorphisms and body composition in young and elderly women. DESIGN: Population-based association study. METHODS: Four BMP2 SNPs studied. Total body fat and lean mass measured by DEXA in two cohorts: 'PEAK-25' women aged 25 (+/-0.00) (n=993) and osteoporosis prospective risk assessment (OPRA) women aged 75 (+/-0.00) years (n=1001). RESULTS: We found no association between BMP2 SNPs and fat or lean mass, however, we observed consistent although non-significant trends. Polymorphisms, rs235767 and Ser37Ala, exerted opposing effects on most parameters of soft tissue and bone mass in both cohorts. This relationship appeared to be age specific with large differences between alleles observed (fat mass; Ser37Ala: 14.3% (PEAK-25), -3.5% (OPRA)). These initial results appear to suggest that alleles exerting a beneficial effect in young women may subsequently contribute to phenotypes associated with osteoporosis risk in elderly women. CONCLUSIONS: While further analyses in other comparative populations are necessary, in this study of almost 2000 women we observed interesting, although non-significant trends, regarding the effects of variation in the BMP2 gene on parameters of body mass. Although the exact nature of the relationship remains uncertain, we suggest that the mechanisms are influenced by age and environmental factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology
volume
158
issue
5
pages
661 - 668
publisher
Society of the European Journal of Endocrinology
external identifiers
  • wos:000255789200009
  • pmid:18426824
  • scopus:43149111775
ISSN
1479-683X
DOI
10.1530/EJE-07-0757
language
English
LU publication?
yes
id
43cf6bf3-a9f0-49e9-b131-c7ba89272e6c (old id 1147158)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18426824?dopt=Abstract
date added to LUP
2008-05-06 14:30:43
date last changed
2017-01-01 07:30:00
@article{43cf6bf3-a9f0-49e9-b131-c7ba89272e6c,
  abstract     = {OBJECTIVE: Bone morphogenetic protein-2 (BMP2) plays a critical role in osteoblastogenesis and adipogenesis from osteoprogenitor cells. The balance between osteogenic and adipogenic effects is influenced by BMP2 concentration, transcription factors and age. BMP2 single nucleotide polymorphisms (SNPs) may contribute to osteoporosis risk, but the relationship between adiposity and body composition has not been explored. We investigated the relationship between BMP2 polymorphisms and body composition in young and elderly women. DESIGN: Population-based association study. METHODS: Four BMP2 SNPs studied. Total body fat and lean mass measured by DEXA in two cohorts: 'PEAK-25' women aged 25 (+/-0.00) (n=993) and osteoporosis prospective risk assessment (OPRA) women aged 75 (+/-0.00) years (n=1001). RESULTS: We found no association between BMP2 SNPs and fat or lean mass, however, we observed consistent although non-significant trends. Polymorphisms, rs235767 and Ser37Ala, exerted opposing effects on most parameters of soft tissue and bone mass in both cohorts. This relationship appeared to be age specific with large differences between alleles observed (fat mass; Ser37Ala: 14.3% (PEAK-25), -3.5% (OPRA)). These initial results appear to suggest that alleles exerting a beneficial effect in young women may subsequently contribute to phenotypes associated with osteoporosis risk in elderly women. CONCLUSIONS: While further analyses in other comparative populations are necessary, in this study of almost 2000 women we observed interesting, although non-significant trends, regarding the effects of variation in the BMP2 gene on parameters of body mass. Although the exact nature of the relationship remains uncertain, we suggest that the mechanisms are influenced by age and environmental factors.},
  author       = {McGuigan, Fiona and Larzenius, Emma and Callréus, Mattias and Gerdhem, Paul and Luthman, Holger and Åkesson, Kristina},
  issn         = {1479-683X},
  language     = {eng},
  number       = {5},
  pages        = {661--668},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {Variation in the bone morphogenetic protein-2 gene: effects on fat and lean body mass in young and elderly women.},
  url          = {http://dx.doi.org/10.1530/EJE-07-0757},
  volume       = {158},
  year         = {2008},
}