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Breastfeeding does not influence the development of inhibitors in haemophilia.

Knobe, Karin LU ; Tengborn, Lilian LU ; Petrini, P and Ljung, Rolf LU (2002) In Haemophilia 8(5). p.657-659
Abstract
Our aim was to test the hypothesis that breastfeeding may reduce development of inhibitors in male infants with haemophilia by inducing an oral immune tolerance to factor VIII. To achieve that goal, we performed a structured epidemiological survey comprising all males born with severe haemophilia A (in all 100 patients, 19 with inhibitors) or haemophilia B (in all 16 patients, six with inhibitors) in Sweden in 1980-99. Our results show no protective effect of breastfeeding.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Immune Tolerance, Hemophilia A: immunology, Hemophilia B: immunology, Human, Preschool, Factor VIII: metabolism, Infant, Newborn, Male, Sweden, Autoantibodies: blood, Blood Coagulation Factor Inhibitors: metabolism, Breast Feeding, Child
in
Haemophilia
volume
8
issue
5
pages
657 - 659
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000177704400008
  • pmid:12199675
  • scopus:0036735251
ISSN
1351-8216
DOI
10.1046/j.1365-2516.2002.00655.x
language
English
LU publication?
yes
id
d48bca4a-3f14-4c31-95de-7ad6c67c2960 (old id 114970)
date added to LUP
2007-07-24 16:03:51
date last changed
2017-01-01 04:34:30
@article{d48bca4a-3f14-4c31-95de-7ad6c67c2960,
  abstract     = {Our aim was to test the hypothesis that breastfeeding may reduce development of inhibitors in male infants with haemophilia by inducing an oral immune tolerance to factor VIII. To achieve that goal, we performed a structured epidemiological survey comprising all males born with severe haemophilia A (in all 100 patients, 19 with inhibitors) or haemophilia B (in all 16 patients, six with inhibitors) in Sweden in 1980-99. Our results show no protective effect of breastfeeding.},
  author       = {Knobe, Karin and Tengborn, Lilian and Petrini, P and Ljung, Rolf},
  issn         = {1351-8216},
  keyword      = {Immune Tolerance,Hemophilia A: immunology,Hemophilia B: immunology,Human,Preschool,Factor VIII: metabolism,Infant,Newborn,Male,Sweden,Autoantibodies: blood,Blood Coagulation Factor Inhibitors: metabolism,Breast Feeding,Child},
  language     = {eng},
  number       = {5},
  pages        = {657--659},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {Breastfeeding does not influence the development of inhibitors in haemophilia.},
  url          = {http://dx.doi.org/10.1046/j.1365-2516.2002.00655.x},
  volume       = {8},
  year         = {2002},
}