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Parity in relation to survival following breast cancer.

Butt, Salma LU ; Borgquist, Signe LU ; Garne, J P; Landberg, Göran LU ; Tengrup, Ingrid LU ; Olsson, A and Manjer, Jonas LU (2009) In European Journal of Surgical Oncology 35. p.702-708
Abstract
AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of parity. Corresponding relative risks, with 95% confidence intervals (CI), were obtained using Cox's proportional hazards analysis. All analyses were adjusted for potential prognostic factors and stratified for age, menopausal status and diagnostic period. RESULTS: As compared to women with one child, nulliparity (RR 1.27: 95% CI 1.09-1.47), and... (More)
AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of parity. Corresponding relative risks, with 95% confidence intervals (CI), were obtained using Cox's proportional hazards analysis. All analyses were adjusted for potential prognostic factors and stratified for age, menopausal status and diagnostic period. RESULTS: As compared to women with one child, nulliparity (RR 1.27: 95% CI 1.09-1.47), and high parity (four or more children) (1.49: 1.20-1.85) were positively associated with a high mortality from breast cancer. When adjusted for potential confounders, the association was only statistically significant for high parity (1.33: 1.07-1.66). In the analyses stratified on age and menopausal status, there was a similar positive association between high parity and breast cancer death in all strata, although only statistically significant among women older than 45years of age or postmenopausal. Nulliparity was associated with breast cancer death in women that were younger than 45years of age (1.28: 0.79-2.09) or premenopausal (1.30: 0.95-1.80), but these associations did not reach statistical significance. There was no association between nulliparity and breast cancer death in women older than 45years of age or postmenopausal. All associations were similar in analyses stratified for diagnostic period. CONCLUSION: Women with four or more children have a poor breast cancer survival as compared to women with one child. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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in
European Journal of Surgical Oncology
volume
35
pages
702 - 708
publisher
Elsevier
external identifiers
  • wos:000267301700005
  • pmid:18490128
  • scopus:67349176099
ISSN
1532-2157
DOI
10.1016/j.ejso.2008.03.017
language
English
LU publication?
yes
id
b30811e9-7ece-4802-b6b4-3e1857993b79 (old id 1153970)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18490128?dopt=Abstract
date added to LUP
2008-06-04 10:59:43
date last changed
2017-11-05 04:42:02
@article{b30811e9-7ece-4802-b6b4-3e1857993b79,
  abstract     = {AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of parity. Corresponding relative risks, with 95% confidence intervals (CI), were obtained using Cox's proportional hazards analysis. All analyses were adjusted for potential prognostic factors and stratified for age, menopausal status and diagnostic period. RESULTS: As compared to women with one child, nulliparity (RR 1.27: 95% CI 1.09-1.47), and high parity (four or more children) (1.49: 1.20-1.85) were positively associated with a high mortality from breast cancer. When adjusted for potential confounders, the association was only statistically significant for high parity (1.33: 1.07-1.66). In the analyses stratified on age and menopausal status, there was a similar positive association between high parity and breast cancer death in all strata, although only statistically significant among women older than 45years of age or postmenopausal. Nulliparity was associated with breast cancer death in women that were younger than 45years of age (1.28: 0.79-2.09) or premenopausal (1.30: 0.95-1.80), but these associations did not reach statistical significance. There was no association between nulliparity and breast cancer death in women older than 45years of age or postmenopausal. All associations were similar in analyses stratified for diagnostic period. CONCLUSION: Women with four or more children have a poor breast cancer survival as compared to women with one child.},
  author       = {Butt, Salma and Borgquist, Signe and Garne, J P and Landberg, Göran and Tengrup, Ingrid and Olsson, A and Manjer, Jonas},
  issn         = {1532-2157},
  language     = {eng},
  pages        = {702--708},
  publisher    = {Elsevier},
  series       = {European Journal of Surgical Oncology},
  title        = {Parity in relation to survival following breast cancer.},
  url          = {http://dx.doi.org/10.1016/j.ejso.2008.03.017},
  volume       = {35},
  year         = {2009},
}