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Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk.

Ivaska, Kaisa LU ; Lenora, Janaka; Gerdhem, Paul LU ; Åkesson, Kristina LU ; Väänänen, H Kalervo and Obrant, Karl LU (2008) In Journal of Clinical Endocrinology and Metabolism May 6. p.2622-2632
Abstract
Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3 and 5 years. Setting: Population-based study. Participants: 1044 women, all 75 years old at baseline. Main outcome measures: Seven bone turnover markers were assessed at baseline, 1, 3 and 5 years (n=573). Five year change in areal bone mineral density (aBMD) was also determined. Results: Baseline markers correlated... (More)
Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3 and 5 years. Setting: Population-based study. Participants: 1044 women, all 75 years old at baseline. Main outcome measures: Seven bone turnover markers were assessed at baseline, 1, 3 and 5 years (n=573). Five year change in areal bone mineral density (aBMD) was also determined. Results: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-year measurements was used (standardized regression coefficients -0.12 to -0.23, p<0.01). Adding the 3-year and 5-year measurement further strengthened the correlation (regression coefficients up to -0.30 (p<0.001)). Women with constantly high turnover lost significantly more bone at total body (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, p for trend <0.001). They also had a greater decrease in hip BMD (-8.3%, -6.0% and -5.1%, respectively, p=0.010). Results were similar also in the subgroup of women with osteopenia. Conclusions: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
May 6
pages
2622 - 2632
publisher
The Endocrine Society
external identifiers
  • WOS:000257513700033
  • PMID:18460567
  • Scopus:47549095521
ISSN
1945-7197
DOI
10.1210/jc.2007-1508
language
English
LU publication?
yes
id
a5f53acc-5d7f-4895-9f66-028932890e1e (old id 1154520)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18460567?dopt=Abstract
date added to LUP
2008-06-02 13:54:25
date last changed
2017-01-01 07:44:23
@article{a5f53acc-5d7f-4895-9f66-028932890e1e,
  abstract     = {Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3 and 5 years. Setting: Population-based study. Participants: 1044 women, all 75 years old at baseline. Main outcome measures: Seven bone turnover markers were assessed at baseline, 1, 3 and 5 years (n=573). Five year change in areal bone mineral density (aBMD) was also determined. Results: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-year measurements was used (standardized regression coefficients -0.12 to -0.23, p&lt;0.01). Adding the 3-year and 5-year measurement further strengthened the correlation (regression coefficients up to -0.30 (p&lt;0.001)). Women with constantly high turnover lost significantly more bone at total body (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, p for trend &lt;0.001). They also had a greater decrease in hip BMD (-8.3%, -6.0% and -5.1%, respectively, p=0.010). Results were similar also in the subgroup of women with osteopenia. Conclusions: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk.},
  author       = {Ivaska, Kaisa and Lenora, Janaka and Gerdhem, Paul and Åkesson, Kristina and Väänänen, H Kalervo and Obrant, Karl},
  issn         = {1945-7197},
  language     = {eng},
  pages        = {2622--2632},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk.},
  url          = {http://dx.doi.org/10.1210/jc.2007-1508},
  volume       = {May 6},
  year         = {2008},
}