Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk.
(2008) In Journal of Clinical Endocrinology and Metabolism May 6. p.2622-2632- Abstract
- Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3 and 5 years. Setting: Population-based study. Participants: 1044 women, all 75 years old at baseline. Main outcome measures: Seven bone turnover markers were assessed at baseline, 1, 3 and 5 years (n=573). Five year change in areal bone mineral density (aBMD) was also determined. Results: Baseline markers correlated... (More)
- Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3 and 5 years. Setting: Population-based study. Participants: 1044 women, all 75 years old at baseline. Main outcome measures: Seven bone turnover markers were assessed at baseline, 1, 3 and 5 years (n=573). Five year change in areal bone mineral density (aBMD) was also determined. Results: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-year measurements was used (standardized regression coefficients -0.12 to -0.23, p<0.01). Adding the 3-year and 5-year measurement further strengthened the correlation (regression coefficients up to -0.30 (p<0.001)). Women with constantly high turnover lost significantly more bone at total body (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, p for trend <0.001). They also had a greater decrease in hip BMD (-8.3%, -6.0% and -5.1%, respectively, p=0.010). Results were similar also in the subgroup of women with osteopenia. Conclusions: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1154520
- author
- Ivaska, Kaisa LU ; Lenora, Janaka ; Gerdhem, Paul LU ; Åkesson, Kristina LU ; Väänänen, H Kalervo and Obrant, Karl LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- May 6
- pages
- 2622 - 2632
- publisher
- Oxford University Press
- external identifiers
-
- wos:000257513700033
- pmid:18460567
- scopus:47549095521
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2007-1508
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Clinical and Molecular Osteoporosis Research Unit (013242930)
- id
- a5f53acc-5d7f-4895-9f66-028932890e1e (old id 1154520)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18460567?dopt=Abstract
- date added to LUP
- 2016-04-04 09:11:57
- date last changed
- 2022-04-23 19:25:05
@article{a5f53acc-5d7f-4895-9f66-028932890e1e,
abstract = {{Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3 and 5 years. Setting: Population-based study. Participants: 1044 women, all 75 years old at baseline. Main outcome measures: Seven bone turnover markers were assessed at baseline, 1, 3 and 5 years (n=573). Five year change in areal bone mineral density (aBMD) was also determined. Results: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-year measurements was used (standardized regression coefficients -0.12 to -0.23, p<0.01). Adding the 3-year and 5-year measurement further strengthened the correlation (regression coefficients up to -0.30 (p<0.001)). Women with constantly high turnover lost significantly more bone at total body (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, p for trend <0.001). They also had a greater decrease in hip BMD (-8.3%, -6.0% and -5.1%, respectively, p=0.010). Results were similar also in the subgroup of women with osteopenia. Conclusions: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk.}},
author = {{Ivaska, Kaisa and Lenora, Janaka and Gerdhem, Paul and Åkesson, Kristina and Väänänen, H Kalervo and Obrant, Karl}},
issn = {{1945-7197}},
language = {{eng}},
pages = {{2622--2632}},
publisher = {{Oxford University Press}},
series = {{Journal of Clinical Endocrinology and Metabolism}},
title = {{Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk.}},
url = {{http://dx.doi.org/10.1210/jc.2007-1508}},
doi = {{10.1210/jc.2007-1508}},
volume = {{May 6}},
year = {{2008}},
}