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Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease.

Sun, Yongxin LU ; Minthon, Lennart LU ; Wallmark, A; Warkentin, Siegbert LU ; Blennow, K and Janciauskiene, Sabina LU (2003) In Dementia and Geriatric Cognitive Disorders 16(3). p.136-144
Abstract
It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels of alpha1-antichymotrypsin (ACT), alpha1-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 patients with probable AD. We found a significant relationship between CSF and plasma levels of ACT (r = 0.4, p < 0.001), IL-6 (r = 0.74, p < 0.001), MCP-1 (r = 0.71, p < 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 0.22, p < 0.05). In addition, linear regression analysis revealed a positive correlation between levels of... (More)
It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels of alpha1-antichymotrypsin (ACT), alpha1-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 patients with probable AD. We found a significant relationship between CSF and plasma levels of ACT (r = 0.4, p < 0.001), IL-6 (r = 0.74, p < 0.001), MCP-1 (r = 0.71, p < 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 0.22, p < 0.05). In addition, linear regression analysis revealed a positive correlation between levels of CSF-ACT and oxLDL (p < 0.001), but an inverse relation between levels of CSF ACT, CSF AAT and MCP-1 (p < 0.001). A significant correlation was also found between levels of CSF ACT, oxLDL and the ratio of CSF to serum albumin, which is used as a measure of the blood-brain barrier function. Our data extend previous reports regarding the inflammatory markers in the plasma and CSF of patients with AD and provide good evidence that levels of ACT, IL-6, MCP-1 and oxLDL in plasma and CSF might be candidates as biomarkers for monitoring the inflammatory process in AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
16
issue
3
pages
136 - 144
publisher
Karger
external identifiers
  • pmid:12826739
  • wos:000184152400004
  • scopus:0038115686
ISSN
1420-8008
DOI
10.1159/000071001
language
English
LU publication?
yes
id
3d89dc13-48d0-4fe4-9d31-95f1492a59dc (old id 115658)
date added to LUP
2007-07-30 14:33:48
date last changed
2018-02-04 03:29:54
@article{3d89dc13-48d0-4fe4-9d31-95f1492a59dc,
  abstract     = {It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels of alpha1-antichymotrypsin (ACT), alpha1-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 patients with probable AD. We found a significant relationship between CSF and plasma levels of ACT (r = 0.4, p &lt; 0.001), IL-6 (r = 0.74, p &lt; 0.001), MCP-1 (r = 0.71, p &lt; 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 0.22, p &lt; 0.05). In addition, linear regression analysis revealed a positive correlation between levels of CSF-ACT and oxLDL (p &lt; 0.001), but an inverse relation between levels of CSF ACT, CSF AAT and MCP-1 (p &lt; 0.001). A significant correlation was also found between levels of CSF ACT, oxLDL and the ratio of CSF to serum albumin, which is used as a measure of the blood-brain barrier function. Our data extend previous reports regarding the inflammatory markers in the plasma and CSF of patients with AD and provide good evidence that levels of ACT, IL-6, MCP-1 and oxLDL in plasma and CSF might be candidates as biomarkers for monitoring the inflammatory process in AD.},
  author       = {Sun, Yongxin and Minthon, Lennart and Wallmark, A and Warkentin, Siegbert and Blennow, K and Janciauskiene, Sabina},
  issn         = {1420-8008},
  language     = {eng},
  number       = {3},
  pages        = {136--144},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1159/000071001},
  volume       = {16},
  year         = {2003},
}