Cardiovascular autonomic neuropathy associated with carotid atherosclerosis in Type 2 diabetic patients.
(2003) In Diabetic Medicine 20(6). p.495-499- Abstract
- AimsTo clarify if cardiovascular autonomic neuropathy is associated with carotid artery atherosclerotic plaques in Type 2 diabetic patients.
MethodsCardiovascular autonomic nerve function was related to carotid artery ultrasound in 61 Type 2 diabetic patients 5-6 years after diagnosis of diabetes.
ResultsCardiovascular autonomic neuropathy [abnormal age corrected expiration/inspiration (E/I) ratio or acceleration index (AI)] was found in 13/61 (21%) patients. Patients with cardiovascular autonomic neuropathy showed increased degree of stenosis in the common carotid artery (24.6 ± 13.2% vs. 14.7 ± 9.2%; P = 0.014) and a tendency towards a higher plaque score (4.0 ± 1.7 vs. 3.2 ± 1.6; P = 0.064).... (More) - AimsTo clarify if cardiovascular autonomic neuropathy is associated with carotid artery atherosclerotic plaques in Type 2 diabetic patients.
MethodsCardiovascular autonomic nerve function was related to carotid artery ultrasound in 61 Type 2 diabetic patients 5-6 years after diagnosis of diabetes.
ResultsCardiovascular autonomic neuropathy [abnormal age corrected expiration/inspiration (E/I) ratio or acceleration index (AI)] was found in 13/61 (21%) patients. Patients with cardiovascular autonomic neuropathy showed increased degree of stenosis in the common carotid artery (24.6 ± 13.2% vs. 14.7 ± 9.2%; P = 0.014) and a tendency towards a higher plaque score (4.0 ± 1.7 vs. 3.2 ± 1.6; P = 0.064). Controlled for age, AI correlated inversely with degree of stenosis (r = -0.39; P = 0.005), plaque score (r = -0.39; P = 0.005), and mean (r = -0.33; P = 0.018) and maximum (r = -0.39; P = 0.004) intima-media thickness in the common carotid artery. In contrast, E/I ratio correlated only slightly with mean intima-media thickness in the common carotid artery (r = -0.28; P = 0.049).
ConclusionsCardiovascular autonomic neuropathy was associated with carotid atherosclerosis in Type 2 diabetic patients. Abnormal E/I ratios reflect efferent structural damage to parasympathetic nerves whereas abnormal AI reflects afferent autonomic dysfunction possibly due to impaired baroreceptor sensitivity secondary to carotid atherosclerosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/116166
- author
- Gottsäter, Anders LU ; Rydén Ahlgren, Åsa LU ; Szelag, Beata LU ; Hedblad, Bo LU ; Persson, J ; Berglund, Göran LU ; Wroblewski, M and Sundkvist, Göran LU
- organization
-
- Vascular Diseases - Clinical Research (research group)
- Clinical Physiology and Nuclear Medicine, Malmö (research group)
- Geriatric Medicine (research group)
- Cardiovascular Research - Epidemiology (research group)
- Internal Medicine - Epidemiology (research group)
- Department of Clinical Sciences, Malmö
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine
- volume
- 20
- issue
- 6
- pages
- 495 - 499
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000183203300013
- scopus:0038460758
- ISSN
- 1464-5491
- DOI
- 10.1046/j.1464-5491.2003.00956.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes Epidemiology and Neuropathy (013241560), Internal Medicine Research Unit (013242520), Division of Geriatric Medicine (013040040), Cardio-vascular Epidemiology (013241610), Clinical Physiology and Nuclear Medicine Unit (013242320), Unit for Clinical Vascular Disease Research (013242410)
- id
- 69591776-1780-4e72-9a5d-f7cf0b80a2d1 (old id 116166)
- date added to LUP
- 2016-04-01 16:36:34
- date last changed
- 2023-09-18 21:43:11
@article{69591776-1780-4e72-9a5d-f7cf0b80a2d1, abstract = {{AimsTo clarify if cardiovascular autonomic neuropathy is associated with carotid artery atherosclerotic plaques in Type 2 diabetic patients.<br/><br> <br/><br> MethodsCardiovascular autonomic nerve function was related to carotid artery ultrasound in 61 Type 2 diabetic patients 5-6 years after diagnosis of diabetes.<br/><br> <br/><br> ResultsCardiovascular autonomic neuropathy [abnormal age corrected expiration/inspiration (E/I) ratio or acceleration index (AI)] was found in 13/61 (21%) patients. Patients with cardiovascular autonomic neuropathy showed increased degree of stenosis in the common carotid artery (24.6 ± 13.2% vs. 14.7 ± 9.2%; P = 0.014) and a tendency towards a higher plaque score (4.0 ± 1.7 vs. 3.2 ± 1.6; P = 0.064). Controlled for age, AI correlated inversely with degree of stenosis (r = -0.39; P = 0.005), plaque score (r = -0.39; P = 0.005), and mean (r = -0.33; P = 0.018) and maximum (r = -0.39; P = 0.004) intima-media thickness in the common carotid artery. In contrast, E/I ratio correlated only slightly with mean intima-media thickness in the common carotid artery (r = -0.28; P = 0.049).<br/><br> <br/><br> ConclusionsCardiovascular autonomic neuropathy was associated with carotid atherosclerosis in Type 2 diabetic patients. Abnormal E/I ratios reflect efferent structural damage to parasympathetic nerves whereas abnormal AI reflects afferent autonomic dysfunction possibly due to impaired baroreceptor sensitivity secondary to carotid atherosclerosis.}}, author = {{Gottsäter, Anders and Rydén Ahlgren, Åsa and Szelag, Beata and Hedblad, Bo and Persson, J and Berglund, Göran and Wroblewski, M and Sundkvist, Göran}}, issn = {{1464-5491}}, language = {{eng}}, number = {{6}}, pages = {{495--499}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine}}, title = {{Cardiovascular autonomic neuropathy associated with carotid atherosclerosis in Type 2 diabetic patients.}}, url = {{https://lup.lub.lu.se/search/files/4723461/623821.pdf}}, doi = {{10.1046/j.1464-5491.2003.00956.x}}, volume = {{20}}, year = {{2003}}, }