Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel
(2008) In International Journal of Pharmaceutics 358(1-2). p.36-43- Abstract
- Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1165981
- author
- Ivanov, Alexander LU ; Nilsson, Lars LU ; Galaev, Igor LU and Mattiasson, Bo LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Mucoadhesive, Drug delivery, Boronic acid, Controlled release, Smart material
- in
- International Journal of Pharmaceutics
- volume
- 358
- issue
- 1-2
- pages
- 36 - 43
- publisher
- Elsevier
- external identifiers
-
- pmid:18394833
- wos:000257577400005
- scopus:44449157070
- pmid:18394833
- ISSN
- 1873-3476
- DOI
- 10.1016/j.ijpharm.2008.02.017
- language
- English
- LU publication?
- yes
- id
- e23f2f82-03e4-4822-813f-42861af0b018 (old id 1165981)
- date added to LUP
- 2016-04-01 11:53:25
- date last changed
- 2023-09-01 11:17:46
@article{e23f2f82-03e4-4822-813f-42861af0b018, abstract = {{Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.}}, author = {{Ivanov, Alexander and Nilsson, Lars and Galaev, Igor and Mattiasson, Bo}}, issn = {{1873-3476}}, keywords = {{Mucoadhesive; Drug delivery; Boronic acid; Controlled release; Smart material}}, language = {{eng}}, number = {{1-2}}, pages = {{36--43}}, publisher = {{Elsevier}}, series = {{International Journal of Pharmaceutics}}, title = {{Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel}}, url = {{http://dx.doi.org/10.1016/j.ijpharm.2008.02.017}}, doi = {{10.1016/j.ijpharm.2008.02.017}}, volume = {{358}}, year = {{2008}}, }