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Cube Copying Test in Combination with rCBF or CSF Abeta(42)Predicts Development of Alzheimer's Disease.

Buchhave, Peder LU ; Stomrud, Erik LU orcid ; Warkentin, Siegbert LU ; Blennow, Kaj ; Minthon, Lennart LU and Hansson, Oskar LU orcid (2008) In Dementia and Geriatric Cognitive Disorders 25(6). p.544-552
Abstract
Background/Aim: The aim was to identify subjects with incipient Alzheimer's disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests. Methods: A total of 147 MCI patients were followed for 4-6 years and the incidence of AD was 11.6%/year. At baseline, the cube copying test, clock drawing test, MMSE and measurements of regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) beta-amyloid(1-42) (Abeta(42)) were performed. Results: The cube copying test, but not the clock drawing test, could predict AD among MCI patients with an area under the receiver operating characteristic curve of 0.64 (p < 0.01). The relative risk for future AD was increased in MCI subjects with impaired cube copying test... (More)
Background/Aim: The aim was to identify subjects with incipient Alzheimer's disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests. Methods: A total of 147 MCI patients were followed for 4-6 years and the incidence of AD was 11.6%/year. At baseline, the cube copying test, clock drawing test, MMSE and measurements of regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) beta-amyloid(1-42) (Abeta(42)) were performed. Results: The cube copying test, but not the clock drawing test, could predict AD among MCI patients with an area under the receiver operating characteristic curve of 0.64 (p < 0.01). The relative risk for future AD was increased in MCI subjects with impaired cube copying test (sex- and age-adjusted hazard ratio = 1.8, p < 0.05) and the incidence of AD was 18.2% in this subgroup. Combining the cube copying test with either rCBF or CSF Abeta(42) had additive effects on the risk assessment for future development of AD. MCI patients achieving high scores on both MMSE and cube copying test had a very low risk of developing AD (incidence of AD = 1.6%). Conclusion: In conclusion, combinations of the cube copying test with MMSE, rCBF and CSF Abeta(42) measurements can identify subgroups of MCI subjects with either substantially reduced or increased risk for future development of AD. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
25
issue
6
pages
544 - 552
publisher
Karger
external identifiers
  • pmid:18535375
  • wos:000257515500009
  • scopus:46849083714
  • pmid:18535375
ISSN
1420-8008
DOI
10.1159/000137379
language
English
LU publication?
yes
id
87dd1abb-eeaa-474b-8aa3-0d00e1e3dcde (old id 1169068)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18535375?dopt=Abstract
date added to LUP
2016-04-01 12:09:30
date last changed
2023-11-11 15:01:16
@article{87dd1abb-eeaa-474b-8aa3-0d00e1e3dcde,
  abstract     = {{Background/Aim: The aim was to identify subjects with incipient Alzheimer's disease (AD) among patients with mild cognitive impairment (MCI) using brief cognitive tests. Methods: A total of 147 MCI patients were followed for 4-6 years and the incidence of AD was 11.6%/year. At baseline, the cube copying test, clock drawing test, MMSE and measurements of regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) beta-amyloid(1-42) (Abeta(42)) were performed. Results: The cube copying test, but not the clock drawing test, could predict AD among MCI patients with an area under the receiver operating characteristic curve of 0.64 (p &lt; 0.01). The relative risk for future AD was increased in MCI subjects with impaired cube copying test (sex- and age-adjusted hazard ratio = 1.8, p &lt; 0.05) and the incidence of AD was 18.2% in this subgroup. Combining the cube copying test with either rCBF or CSF Abeta(42) had additive effects on the risk assessment for future development of AD. MCI patients achieving high scores on both MMSE and cube copying test had a very low risk of developing AD (incidence of AD = 1.6%). Conclusion: In conclusion, combinations of the cube copying test with MMSE, rCBF and CSF Abeta(42) measurements can identify subgroups of MCI subjects with either substantially reduced or increased risk for future development of AD.}},
  author       = {{Buchhave, Peder and Stomrud, Erik and Warkentin, Siegbert and Blennow, Kaj and Minthon, Lennart and Hansson, Oskar}},
  issn         = {{1420-8008}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{544--552}},
  publisher    = {{Karger}},
  series       = {{Dementia and Geriatric Cognitive Disorders}},
  title        = {{Cube Copying Test in Combination with rCBF or CSF Abeta(42)Predicts Development of Alzheimer's Disease.}},
  url          = {{http://dx.doi.org/10.1159/000137379}},
  doi          = {{10.1159/000137379}},
  volume       = {{25}},
  year         = {{2008}},
}