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Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt.

Brundin, Lena LU ; Björkqvist, Maria LU ; Träskman Bendz, Lil LU and Petersén, Åsa LU (2009) In Journal of Affective Disorders Jun 2. p.179-182
Abstract
BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness)... (More)
BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score. LIMITATIONS: The number of patients who participated was relatively small. CONCLUSIONS: Our results support the hypothesis that orexin is involved in psychiatric symptomatology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Affective Disorders
volume
Jun 2
pages
179 - 182
publisher
Elsevier
external identifiers
  • wos:000263007500020
  • pmid:18533274
  • scopus:58149093295
ISSN
1573-2517
DOI
10.1016/j.jad.2008.04.011
language
English
LU publication?
yes
id
c624a9e8-5ad1-4e00-bd18-0bc393484599 (old id 1169096)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18533274?dopt=Abstract
date added to LUP
2008-07-03 09:43:58
date last changed
2017-06-18 04:37:28
@article{c624a9e8-5ad1-4e00-bd18-0bc393484599,
  abstract     = {BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score. LIMITATIONS: The number of patients who participated was relatively small. CONCLUSIONS: Our results support the hypothesis that orexin is involved in psychiatric symptomatology.},
  author       = {Brundin, Lena and Björkqvist, Maria and Träskman Bendz, Lil and Petersén, Åsa},
  issn         = {1573-2517},
  language     = {eng},
  pages        = {179--182},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt.},
  url          = {http://dx.doi.org/10.1016/j.jad.2008.04.011},
  volume       = {Jun 2},
  year         = {2009},
}