PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Mootha, VK ; Lindgren, Cecilia LU ; Eriksson, Karl-Fredrik LU ; Subramanian, A ; Sihag, S ; Lehar, J ; Puigserver, P ; Nilsson, Emma A LU
; Ridderstråle, Martin
LU
and Laurila, Esa
LU
, et al.
(2003)
In Nature Genetics
34(3).
p.267-273
- Abstract
- DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important... (More)
- DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/117054
- author
- Mootha, VK
; Lindgren, Cecilia
LU
; Eriksson, Karl-Fredrik
LU
; Subramanian, A
; Sihag, S
; Lehar, J
; Puigserver, P
; Nilsson, Emma A
LU
; Ridderstråle, Martin
LU
and Laurila, Esa
LU
, et al. (More)
- Mootha, VK
; Lindgren, Cecilia
LU
; Eriksson, Karl-Fredrik
LU
; Subramanian, A
; Sihag, S
; Lehar, J
; Puigserver, P
; Nilsson, Emma A
LU
; Ridderstråle, Martin
LU
; Laurila, Esa
LU
; Houstis, N
; Daly, MJ
; Patterson, N
; Mesirov, JP
; Golub, TR
; Tamayo, P
; Spiegelman, B
; Lander, ES
; Hirschhorn, JN
; Altshuler, D
and Groop, Leif
LU
(Less)
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 34
- issue
- 3
- pages
- 267 - 273
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:12808457
- wos:000183815300013
- scopus:0038054341
- ISSN
- 1546-1718
- DOI
- 10.1038/ng1180
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Unit for Clinical Vascular Disease Research (013242410), Clinical Obesity (013241521), Diabetes and Endocrinology (013241530)
- id
- 7bb5f6c1-6141-4fe9-bcb4-b3b05f89ebaf (old id 117054)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12808457&dopt=Abstract
- date added to LUP
- 2016-04-01 16:04:54
- date last changed
- 2024-04-11 16:56:18
@article{7bb5f6c1-6141-4fe9-bcb4-b3b05f89ebaf,
abstract = {{DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments.}},
author = {{Mootha, VK and Lindgren, Cecilia and Eriksson, Karl-Fredrik and Subramanian, A and Sihag, S and Lehar, J and Puigserver, P and Nilsson, Emma A and Ridderstråle, Martin and Laurila, Esa and Houstis, N and Daly, MJ and Patterson, N and Mesirov, JP and Golub, TR and Tamayo, P and Spiegelman, B and Lander, ES and Hirschhorn, JN and Altshuler, D and Groop, Leif}},
issn = {{1546-1718}},
language = {{eng}},
number = {{3}},
pages = {{267--273}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.}},
url = {{http://dx.doi.org/10.1038/ng1180}},
doi = {{10.1038/ng1180}},
volume = {{34}},
year = {{2003}},
}