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Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity.

Johansson, Lovisa LU ; Danielsson, Pernilla; Norgren, Svante; Marcus, Claude and Ridderstråle, Martin LU (2009) In International Journal of Pediatric Obesity 4. p.119-125
Abstract
Aim. The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. Methods. Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype. Results. We found no association for PPARG or ADIPOQ polymorphisms with Body Mass Index (BMI), High Density Lipoprotein (HDL)-cholesterol, triglycerides or Insulin Resistance... (More)
Aim. The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. Methods. Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype. Results. We found no association for PPARG or ADIPOQ polymorphisms with Body Mass Index (BMI), High Density Lipoprotein (HDL)-cholesterol, triglycerides or Insulin Resistance estimated by Homeostasis Model of Assessment (HOMA-IR). Wild type carriers of PPARG Pro12Ala (p<0.05), homozygous carriers of the variant allele of ADIPOQ G276T (p<0.001) and epsilon4 carriers of APOE (p<0.001) had higher total and low density lipoprotein (LDL)-cholesterol levels adjusted for age, gender, BMI and insulin sensitivity. A PPARG/ADIPOQ risk genotype combination was identified by analysis of covariance (ANCOVA) comparing all existing combinations. Carriers of PPARG Pro/Pro and ADIPOQ 276 T/T had higher total (5.0 [4.1-5.8] vs. 4.1 [3.6-4.6]mmol/l) and LDL-cholesterol levels (3.7 [2.9-4.5] vs. 3.0 [2.5-3.5]mmol/l) compared with carriers of other combinations (p<0.001). Importantly, the PPARG and ADIPOQ associations were unaffected when adjusting for APOE genotype. Conclusions. Genetic variants in candidate genes for insulin resistance are associated with cholesterol levels in obese children and adolescents, and may offer additional information in the risk assessment of obese children. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Pediatric Obesity
volume
4
pages
119 - 125
publisher
Taylor & Francis
external identifiers
  • wos:000266085600008
  • pmid:18645733
  • scopus:67649132708
ISSN
1747-7174
DOI
10.1080/17477160802263194
language
English
LU publication?
yes
id
ae1f4b24-d654-40d0-92bb-86489316da7a (old id 1180909)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18645733?dopt=Abstract
date added to LUP
2008-08-11 11:50:06
date last changed
2017-01-01 07:39:21
@article{ae1f4b24-d654-40d0-92bb-86489316da7a,
  abstract     = {Aim. The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. Methods. Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype. Results. We found no association for PPARG or ADIPOQ polymorphisms with Body Mass Index (BMI), High Density Lipoprotein (HDL)-cholesterol, triglycerides or Insulin Resistance estimated by Homeostasis Model of Assessment (HOMA-IR). Wild type carriers of PPARG Pro12Ala (p&lt;0.05), homozygous carriers of the variant allele of ADIPOQ G276T (p&lt;0.001) and epsilon4 carriers of APOE (p&lt;0.001) had higher total and low density lipoprotein (LDL)-cholesterol levels adjusted for age, gender, BMI and insulin sensitivity. A PPARG/ADIPOQ risk genotype combination was identified by analysis of covariance (ANCOVA) comparing all existing combinations. Carriers of PPARG Pro/Pro and ADIPOQ 276 T/T had higher total (5.0 [4.1-5.8] vs. 4.1 [3.6-4.6]mmol/l) and LDL-cholesterol levels (3.7 [2.9-4.5] vs. 3.0 [2.5-3.5]mmol/l) compared with carriers of other combinations (p&lt;0.001). Importantly, the PPARG and ADIPOQ associations were unaffected when adjusting for APOE genotype. Conclusions. Genetic variants in candidate genes for insulin resistance are associated with cholesterol levels in obese children and adolescents, and may offer additional information in the risk assessment of obese children.},
  author       = {Johansson, Lovisa and Danielsson, Pernilla and Norgren, Svante and Marcus, Claude and Ridderstråle, Martin},
  issn         = {1747-7174},
  language     = {eng},
  pages        = {119--125},
  publisher    = {Taylor & Francis},
  series       = {International Journal of Pediatric Obesity},
  title        = {Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity.},
  url          = {http://dx.doi.org/10.1080/17477160802263194},
  volume       = {4},
  year         = {2009},
}