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Electroencephalographic response to procedural pain in healthy term newborn infants.

Norman, Elisabeth LU ; Rosén, Ingmar LU ; Vanhatalo, Sampsa; Stjernqvist, Karin LU ; Okland, Ove; Fellman, Vineta LU and Hellström-Westas, Lena LU (2008) In Pediatric Research 64. p.429-434
Abstract
The current study aimed to characterize changes in EEG-related measures after noxious stimuli in neonates, and to assess their potential utility as measures of pain and/or discomfort during neonatal intensive care.Seventy-two healthy term infants were investigated: Twenty-eight had a non skin-breaking pin-prick on the heel, randomized to receive either oral glucose (n=16) or water (n=12) before the stimulus. 21 infants were studied during a venous blood sample from the dorsum of the hand, 23 infants during a capillary heel stick. Behavioral pain responses were assessed with the Premature Infant Pain Profile (PIPP) scale. The stimulus evoked a significant increase in higher frequency components (10-30Hz) which also correlated to behavioral... (More)
The current study aimed to characterize changes in EEG-related measures after noxious stimuli in neonates, and to assess their potential utility as measures of pain and/or discomfort during neonatal intensive care.Seventy-two healthy term infants were investigated: Twenty-eight had a non skin-breaking pin-prick on the heel, randomized to receive either oral glucose (n=16) or water (n=12) before the stimulus. 21 infants were studied during a venous blood sample from the dorsum of the hand, 23 infants during a capillary heel stick. Behavioral pain responses were assessed with the Premature Infant Pain Profile (PIPP) scale. The stimulus evoked a significant increase in higher frequency components (10-30Hz) which also correlated to behavioral measures. The frontotemporal localization of the increased activity with frequency bands similar to electromuscular artifacts and the relation to behavioral measures confirmed that this activity corresponds to an increase in muscle tone. There was no change in frontal EEG asymmetry in any of the groups. The present results indicate that responses in cortical activity recorded by EEG are not useful for clinical assessment of infants' responses to noxious stimuli. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
64
pages
429 - 434
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000259532100019
  • pmid:18594483
  • scopus:55049103675
ISSN
1530-0447
DOI
10.1203/PDR.0b013e3181825487
language
English
LU publication?
yes
id
450f2b94-4d6f-4f1f-8942-79df522c5969 (old id 1181655)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18594483?dopt=Abstract
date added to LUP
2008-08-06 11:05:35
date last changed
2017-06-25 04:34:54
@article{450f2b94-4d6f-4f1f-8942-79df522c5969,
  abstract     = {The current study aimed to characterize changes in EEG-related measures after noxious stimuli in neonates, and to assess their potential utility as measures of pain and/or discomfort during neonatal intensive care.Seventy-two healthy term infants were investigated: Twenty-eight had a non skin-breaking pin-prick on the heel, randomized to receive either oral glucose (n=16) or water (n=12) before the stimulus. 21 infants were studied during a venous blood sample from the dorsum of the hand, 23 infants during a capillary heel stick. Behavioral pain responses were assessed with the Premature Infant Pain Profile (PIPP) scale. The stimulus evoked a significant increase in higher frequency components (10-30Hz) which also correlated to behavioral measures. The frontotemporal localization of the increased activity with frequency bands similar to electromuscular artifacts and the relation to behavioral measures confirmed that this activity corresponds to an increase in muscle tone. There was no change in frontal EEG asymmetry in any of the groups. The present results indicate that responses in cortical activity recorded by EEG are not useful for clinical assessment of infants' responses to noxious stimuli.},
  author       = {Norman, Elisabeth and Rosén, Ingmar and Vanhatalo, Sampsa and Stjernqvist, Karin and Okland, Ove and Fellman, Vineta and Hellström-Westas, Lena},
  issn         = {1530-0447},
  language     = {eng},
  pages        = {429--434},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Electroencephalographic response to procedural pain in healthy term newborn infants.},
  url          = {http://dx.doi.org/10.1203/PDR.0b013e3181825487},
  volume       = {64},
  year         = {2008},
}