Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.
(2008) In Diabetologia 51. p.1623-1630- Abstract
- AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). METHODS: Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. RESULTS: Birth length SDS corrected for... (More)
- AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). METHODS: Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. RESULTS: Birth length SDS corrected for MPH was increased in children developing diabetes compared with all (p < 0.048) and with non-HLA- (p < 0.050) but not with HLA-matched controls. Children developing diabetes had increased height gain at 0 to 18 months of age (p < 0.005). Diabetic children were significantly taller from 6 to 18 months of age when correcting for MPH compared with non-HLA-matched as well as HLA-matched controls, but BMI was not increased. CONCLUSIONS/INTERPRETATION: Birth length SDS was associated with diabetes risk HLA. When corrected for MPH, children developing diabetes were taller at birth than non-HLA- but not taller than HLA-matched controls. Diabetic children had increased MPH-corrected height up to 18 months of age compared with both HLA- and non-HLA-matched controls. High-risk HLA affects prenatal growth, but other factors may explain the increased postnatal linear growth in children developing diabetes. (Less)
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https://lup.lub.lu.se/record/1181689
- author
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- volume
- 51
- pages
- 1623 - 1630
- publisher
- Springer
- external identifiers
-
- wos:000258236200010
- pmid:18592208
- scopus:49249134526
- pmid:18592208
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-008-1074-0
- language
- English
- LU publication?
- yes
- id
- da45b95c-aefd-4f43-87e0-419ae926f6dc (old id 1181689)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18592208?dopt=Abstract
- date added to LUP
- 2016-04-04 08:39:17
- date last changed
- 2024-10-12 18:20:58
@article{da45b95c-aefd-4f43-87e0-419ae926f6dc, abstract = {{AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). METHODS: Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. RESULTS: Birth length SDS corrected for MPH was increased in children developing diabetes compared with all (p < 0.048) and with non-HLA- (p < 0.050) but not with HLA-matched controls. Children developing diabetes had increased height gain at 0 to 18 months of age (p < 0.005). Diabetic children were significantly taller from 6 to 18 months of age when correcting for MPH compared with non-HLA-matched as well as HLA-matched controls, but BMI was not increased. CONCLUSIONS/INTERPRETATION: Birth length SDS was associated with diabetes risk HLA. When corrected for MPH, children developing diabetes were taller at birth than non-HLA- but not taller than HLA-matched controls. Diabetic children had increased MPH-corrected height up to 18 months of age compared with both HLA- and non-HLA-matched controls. High-risk HLA affects prenatal growth, but other factors may explain the increased postnatal linear growth in children developing diabetes.}}, author = {{Larsson, Helena and Hansson, Gertie and Carlsson, Annelie and Cederwall, E and Jonsson, B and Jönsson, B and Larsson, Karin and Lynch, Kristian and Neiderud, J and Lernmark, Åke and Ivarsson, Sten}}, issn = {{1432-0428}}, language = {{eng}}, pages = {{1623--1630}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.}}, url = {{http://dx.doi.org/10.1007/s00125-008-1074-0}}, doi = {{10.1007/s00125-008-1074-0}}, volume = {{51}}, year = {{2008}}, }