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Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.

Larsson, Helena LU ; Hansson, Gertie LU ; Carlsson, Annelie LU ; Cederwall, E; Jonsson, B; Jönsson, B; Larsson, Karin LU ; Lynch, Kristian LU ; Neiderud, J and Lernmark, Åke LU , et al. (2008) In Diabetologia 51. p.1623-1630
Abstract
AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). METHODS: Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. RESULTS: Birth length SDS corrected for... (More)
AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). METHODS: Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. RESULTS: Birth length SDS corrected for MPH was increased in children developing diabetes compared with all (p < 0.048) and with non-HLA- (p < 0.050) but not with HLA-matched controls. Children developing diabetes had increased height gain at 0 to 18 months of age (p < 0.005). Diabetic children were significantly taller from 6 to 18 months of age when correcting for MPH compared with non-HLA-matched as well as HLA-matched controls, but BMI was not increased. CONCLUSIONS/INTERPRETATION: Birth length SDS was associated with diabetes risk HLA. When corrected for MPH, children developing diabetes were taller at birth than non-HLA- but not taller than HLA-matched controls. Diabetic children had increased MPH-corrected height up to 18 months of age compared with both HLA- and non-HLA-matched controls. High-risk HLA affects prenatal growth, but other factors may explain the increased postnatal linear growth in children developing diabetes. (Less)
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Contribution to journal
publication status
published
subject
in
Diabetologia
volume
51
pages
1623 - 1630
publisher
Springer Verlag
external identifiers
  • wos:000258236200010
  • pmid:18592208
  • scopus:49249134526
ISSN
1432-0428
DOI
10.1007/s00125-008-1074-0
language
English
LU publication?
yes
id
da45b95c-aefd-4f43-87e0-419ae926f6dc (old id 1181689)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18592208?dopt=Abstract
date added to LUP
2008-08-06 11:28:29
date last changed
2017-06-25 04:36:05
@article{da45b95c-aefd-4f43-87e0-419ae926f6dc,
  abstract     = {AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BMI SDS during first 18 months of life and whether these parameters are related to HLA genotypes or mid-parental height (MPH). METHODS: Birthweight, birth length, weight and height were obtained from 58 type 1 diabetes children and 155 controls matched for HLA or not in the Diabetes Prediction in Skåne study. RESULTS: Birth length SDS corrected for MPH was increased in children developing diabetes compared with all (p &lt; 0.048) and with non-HLA- (p &lt; 0.050) but not with HLA-matched controls. Children developing diabetes had increased height gain at 0 to 18 months of age (p &lt; 0.005). Diabetic children were significantly taller from 6 to 18 months of age when correcting for MPH compared with non-HLA-matched as well as HLA-matched controls, but BMI was not increased. CONCLUSIONS/INTERPRETATION: Birth length SDS was associated with diabetes risk HLA. When corrected for MPH, children developing diabetes were taller at birth than non-HLA- but not taller than HLA-matched controls. Diabetic children had increased MPH-corrected height up to 18 months of age compared with both HLA- and non-HLA-matched controls. High-risk HLA affects prenatal growth, but other factors may explain the increased postnatal linear growth in children developing diabetes.},
  author       = {Larsson, Helena and Hansson, Gertie and Carlsson, Annelie and Cederwall, E and Jonsson, B and Jönsson, B and Larsson, Karin and Lynch, Kristian and Neiderud, J and Lernmark, Åke and Ivarsson, Sten},
  issn         = {1432-0428},
  language     = {eng},
  pages        = {1623--1630},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes.},
  url          = {http://dx.doi.org/10.1007/s00125-008-1074-0},
  volume       = {51},
  year         = {2008},
}