Cognitive impairment in rats after long-term exposure to GSM-900 mobile phone radiation
Nittby, Henrietta LU ; Grafström, Gustav LU ; Tian, Dongping LU ; Malmgren, Lars LU ; Brun, Arne LU ; Persson, Bertil R LU
; Salford, Leif
LU
and Eberhardt, Jacob
LU
(2008)
In Bioelectromagnetics
29(3).
p.219-232
- Abstract
- Considering the frequent use of mobile phones, we have directed attention to possible implications on cognitive functions. In this study we investigated in a rat model the long-term effects of protracted exposure to Global System for Mobile Communication-900 MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed for 2 h each week for 55 weeks to radio-frequency electromagnetic radiation at different SAR levels (0.6 and 60 mW/kg at the initiation of the experimental period) emitted by a (GSM-900) test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never left the animal house. After this protracted exposure, GSM-900 exposed rats were compared to sham exposed controls. Effects on exploratory... (More)
- Considering the frequent use of mobile phones, we have directed attention to possible implications on cognitive functions. In this study we investigated in a rat model the long-term effects of protracted exposure to Global System for Mobile Communication-900 MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed for 2 h each week for 55 weeks to radio-frequency electromagnetic radiation at different SAR levels (0.6 and 60 mW/kg at the initiation of the experimental period) emitted by a (GSM-900) test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never left the animal house. After this protracted exposure, GSM-900 exposed rats were compared to sham exposed controls. Effects on exploratory behaviour were evaluated in the open-field test, in which no difference was seen. Effects on cognitive functions were evaluated in the episodic-like memory test. In our study, GSM exposed rats had impaired memory for objects and their temporal order of presentation, compared to sham exposed controls (P = 0.02). Detecting the place in which an object was presented was not affected by GSM exposure. Our results suggest significantly reduced memory functions in rats after GSM microwave exposure (P = 0.02). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1183055
- author
- Nittby, Henrietta
LU
; Grafström, Gustav
LU
; Tian, Dongping
LU
; Malmgren, Lars
LU
; Brun, Arne
LU
; Persson, Bertil R
LU
; Salford, Leif
LU
and Eberhardt, Jacob
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- learning, open-field-test, memory, microwaves, episodic-like memory test, exploratory behaviour, anxiety
- in
- Bioelectromagnetics
- volume
- 29
- issue
- 3
- pages
- 219 - 232
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000254479100008
- scopus:41149117406
- pmid:18044737
- ISSN
- 0197-8462
- DOI
- 10.1002/bem.20386
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurosurgery (013026000), Radiation Physics, Lund (013034000), Max-laboratory (011012005), Pathology, (Lund) (013030000)
- id
- 47d46024-ce5f-455b-8101-d0f23c890677 (old id 1183055)
- date added to LUP
- 2016-04-01 12:22:15
- date last changed
- 2022-03-13 17:00:24
@article{47d46024-ce5f-455b-8101-d0f23c890677,
abstract = {{Considering the frequent use of mobile phones, we have directed attention to possible implications on cognitive functions. In this study we investigated in a rat model the long-term effects of protracted exposure to Global System for Mobile Communication-900 MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed for 2 h each week for 55 weeks to radio-frequency electromagnetic radiation at different SAR levels (0.6 and 60 mW/kg at the initiation of the experimental period) emitted by a (GSM-900) test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never left the animal house. After this protracted exposure, GSM-900 exposed rats were compared to sham exposed controls. Effects on exploratory behaviour were evaluated in the open-field test, in which no difference was seen. Effects on cognitive functions were evaluated in the episodic-like memory test. In our study, GSM exposed rats had impaired memory for objects and their temporal order of presentation, compared to sham exposed controls (P = 0.02). Detecting the place in which an object was presented was not affected by GSM exposure. Our results suggest significantly reduced memory functions in rats after GSM microwave exposure (P = 0.02).}},
author = {{Nittby, Henrietta and Grafström, Gustav and Tian, Dongping and Malmgren, Lars and Brun, Arne and Persson, Bertil R and Salford, Leif and Eberhardt, Jacob}},
issn = {{0197-8462}},
keywords = {{learning; open-field-test; memory; microwaves; episodic-like memory test; exploratory behaviour; anxiety}},
language = {{eng}},
number = {{3}},
pages = {{219--232}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Bioelectromagnetics}},
title = {{Cognitive impairment in rats after long-term exposure to GSM-900 mobile phone radiation}},
url = {{http://dx.doi.org/10.1002/bem.20386}},
doi = {{10.1002/bem.20386}},
volume = {{29}},
year = {{2008}},
}