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IL6 and IL1B Polymorphisms are associated with fat mass in older men: The MrOS study Sweden

Strandberg, Louise; Mellstrom, Dan; Ljunggren, Osten; Grundberg, Elin; Karlsson, Magnus LU ; Holmberg, Anna H LU ; Orwoll, Eric S; Eriksson, Anna L; Svedberg, Johan and Bengtsson, Magnus, et al. (2008) In Obesity 16(3). p.710-713
Abstract
There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n = 3,014). The study subjects were from the Swedish part of the MrOS multicenter population study and 69-81 years of age. The IL6-174 G>C (Minor allele frequency (MAF) = 48%) gene promoter polymorphism was associated with the primary outcome total fat mass (P = 0.006) and regional fat masses, but not with lean body mass. The IL1B-31T>C (MAF =... (More)
There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n = 3,014). The study subjects were from the Swedish part of the MrOS multicenter population study and 69-81 years of age. The IL6-174 G>C (Minor allele frequency (MAF) = 48%) gene promoter polymorphism was associated with the primary outcome total fat mass (P = 0.006) and regional fat masses, but not with lean body mass. The IL1B-31T>C (MAF = 34%) polymorphism was also associated with total fat (P = 0.007) and regional fat masses, but not lean body mass. The IL-1 receptor antagonist (IL-1ra) gene (IL1RN) + 2018 T>C (MAF = 27%) polymorphism (in linkage disequilibrium (LD) with a well-studied variable number tandem repeat of 86 base pair (bp)) and IL1B + 3953 C>T (MAF = 26%) polymorphism were not associated with total fat mass. In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men. (Less)
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type
Contribution to journal
publication status
published
subject
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Obesity
volume
16
issue
3
pages
710 - 713
publisher
Nature Publishing Group
external identifiers
  • wos:000253823400031
  • scopus:40149105682
ISSN
1930-739X
DOI
10.1038/oby.2007.95
language
English
LU publication?
yes
id
0478e537-f820-4a96-bb5e-c76290cdb691 (old id 1185922)
date added to LUP
2008-09-03 11:24:10
date last changed
2017-06-04 03:31:48
@article{0478e537-f820-4a96-bb5e-c76290cdb691,
  abstract     = {There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n = 3,014). The study subjects were from the Swedish part of the MrOS multicenter population study and 69-81 years of age. The IL6-174 G>C (Minor allele frequency (MAF) = 48%) gene promoter polymorphism was associated with the primary outcome total fat mass (P = 0.006) and regional fat masses, but not with lean body mass. The IL1B-31T>C (MAF = 34%) polymorphism was also associated with total fat (P = 0.007) and regional fat masses, but not lean body mass. The IL-1 receptor antagonist (IL-1ra) gene (IL1RN) + 2018 T>C (MAF = 27%) polymorphism (in linkage disequilibrium (LD) with a well-studied variable number tandem repeat of 86 base pair (bp)) and IL1B + 3953 C>T (MAF = 26%) polymorphism were not associated with total fat mass. In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men.},
  author       = {Strandberg, Louise and Mellstrom, Dan and Ljunggren, Osten and Grundberg, Elin and Karlsson, Magnus and Holmberg, Anna H and Orwoll, Eric S and Eriksson, Anna L and Svedberg, Johan and Bengtsson, Magnus and Ohlsson, Claes and Jansson, John-Olov},
  issn         = {1930-739X},
  language     = {eng},
  number       = {3},
  pages        = {710--713},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {IL6 and IL1B Polymorphisms are associated with fat mass in older men: The MrOS study Sweden},
  url          = {http://dx.doi.org/10.1038/oby.2007.95},
  volume       = {16},
  year         = {2008},
}