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An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death.

Silver, Christina LU ; Lindgren, Hanna LU ; Pero, Ronald LU ; Leanderson, Tomas LU and Ivars, Fredrik LU (2003) In International Immunopharmacology 3(13-14). p.1889-1900
Abstract
Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these... (More)
Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100® inhibits nuclear factor κB (NF-κB) activity and propose that this at least partially causes the inhibition of proliferation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Inhibition, NF-κB, Uncaria tomentosa, Proliferation, Apoptosis
in
International Immunopharmacology
volume
3
issue
13-14
pages
1889 - 1900
publisher
Elsevier
external identifiers
  • wos:000187038600017
  • pmid:14636838
  • scopus:0242580038
ISSN
1878-1705
DOI
10.1016/j.intimp.2003.07.001
language
English
LU publication?
yes
id
18723ac9-ff7c-4e75-9755-e56a786d50c2 (old id 118656)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14636838&dopt=Abstract
date added to LUP
2007-07-09 15:55:11
date last changed
2017-05-28 03:39:18
@article{18723ac9-ff7c-4e75-9755-e56a786d50c2,
  abstract     = {Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100® inhibits nuclear factor κB (NF-κB) activity and propose that this at least partially causes the inhibition of proliferation.},
  author       = {Silver, Christina and Lindgren, Hanna and Pero, Ronald and Leanderson, Tomas and Ivars, Fredrik},
  issn         = {1878-1705},
  keyword      = {Inhibition,NF-κB,Uncaria tomentosa,Proliferation,Apoptosis},
  language     = {eng},
  number       = {13-14},
  pages        = {1889--1900},
  publisher    = {Elsevier},
  series       = {International Immunopharmacology},
  title        = {An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death.},
  url          = {http://dx.doi.org/10.1016/j.intimp.2003.07.001},
  volume       = {3},
  year         = {2003},
}