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A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage

Bjerre, Pontus LU ; Silfverdal, Lena ; Dillner, Lena LU ; Hagmar, Bjorn ; Edvardsson, Henrik ; Dillner, Joakim LU and Andersson-Ellstrom, Agneta (2008) In American Journal of Obstetrics and Gynecology 199(1). p.1-24
Abstract
OBJECTIVE: This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results. STUDY DESIGN: A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected in organized screening to treatment either (1) if they were positive in a repeat Papanicolaou test smear and/or a human papillomavirus test or (2) if they were positive in the repeat Papanicolaou test smear test only. Women who tested positive were treated, regardless of colposcopic findings. RESULTS: There were 208 of 337 (62%) women who were... (More)
OBJECTIVE: This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results. STUDY DESIGN: A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected in organized screening to treatment either (1) if they were positive in a repeat Papanicolaou test smear and/or a human papillomavirus test or (2) if they were positive in the repeat Papanicolaou test smear test only. Women who tested positive were treated, regardless of colposcopic findings. RESULTS: There were 208 of 337 (62%) women who were treated in the human papillomavirus /Papanicolaou test smear group (187/337 because of HPV positivity) and 138 of 337 (41%) in the Papanicolaou test smear only group. Histopathologically diagnosed cervical intraepithelial neoplasia grade 2 or worse was found among 112 of 337 (33.2%) women in the human papillomavirus/Papanicolaou test smear group compared with 85 of 337 (25.2%) women in the Papanicolaou test smear only group (P < .05). Twenty-one women with cervical intraepithelial neoplasia 2+ had normal colposcopy. CONCLUSION: For adequate cervical intraepithelial neoplasia 2+ sensitivity, the decision to use loop electrosurgical excision procedure needs to be based on human papillomavirus testing results and should not exclude women with normal colposcopy. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
procedure, loop electrosurgical excision, colposcopy, intraepithelial neoplasia, atypical squamous cells of undetermined significance, cervical, randomized trial
in
American Journal of Obstetrics and Gynecology
volume
199
issue
1
pages
1 - 24
publisher
Elsevier
external identifiers
  • wos:000257205200006
  • scopus:45649084756
ISSN
1097-6868
DOI
10.1016/j.ajog.2007.11.053
language
English
LU publication?
yes
id
9662bc8a-6c98-4beb-9d38-6e3b886c90b3 (old id 1187195)
date added to LUP
2016-04-01 11:56:57
date last changed
2022-04-13 03:41:33
@article{9662bc8a-6c98-4beb-9d38-6e3b886c90b3,
  abstract     = {{OBJECTIVE: This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results. STUDY DESIGN: A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected in organized screening to treatment either (1) if they were positive in a repeat Papanicolaou test smear and/or a human papillomavirus test or (2) if they were positive in the repeat Papanicolaou test smear test only. Women who tested positive were treated, regardless of colposcopic findings. RESULTS: There were 208 of 337 (62%) women who were treated in the human papillomavirus /Papanicolaou test smear group (187/337 because of HPV positivity) and 138 of 337 (41%) in the Papanicolaou test smear only group. Histopathologically diagnosed cervical intraepithelial neoplasia grade 2 or worse was found among 112 of 337 (33.2%) women in the human papillomavirus/Papanicolaou test smear group compared with 85 of 337 (25.2%) women in the Papanicolaou test smear only group (P &lt; .05). Twenty-one women with cervical intraepithelial neoplasia 2+ had normal colposcopy. CONCLUSION: For adequate cervical intraepithelial neoplasia 2+ sensitivity, the decision to use loop electrosurgical excision procedure needs to be based on human papillomavirus testing results and should not exclude women with normal colposcopy.}},
  author       = {{Bjerre, Pontus and Silfverdal, Lena and Dillner, Lena and Hagmar, Bjorn and Edvardsson, Henrik and Dillner, Joakim and Andersson-Ellstrom, Agneta}},
  issn         = {{1097-6868}},
  keywords     = {{procedure; loop electrosurgical excision; colposcopy; intraepithelial neoplasia; atypical squamous cells of undetermined significance; cervical; randomized trial}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--24}},
  publisher    = {{Elsevier}},
  series       = {{American Journal of Obstetrics and Gynecology}},
  title        = {{A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage}},
  url          = {{http://dx.doi.org/10.1016/j.ajog.2007.11.053}},
  doi          = {{10.1016/j.ajog.2007.11.053}},
  volume       = {{199}},
  year         = {{2008}},
}