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Effects of FK506 on regeneration and macrophages in injured rat sciatic nerve.

Kvist, Martin LU ; Danielsen, Nils LU and Dahlin, Lars LU (2003) In Journal of the Peripheral Nervous System 8(4). p.251-259
Abstract
Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages.... (More)
Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages. Present and previously published studies may imply that there is a time-related and type-of-injury-related profile of FK506's pro-regenerative effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the Peripheral Nervous System
volume
8
issue
4
pages
251 - 259
publisher
Wiley-Blackwell
external identifiers
  • wos:000187429300007
  • pmid:14641649
  • scopus:0346093573
ISSN
1085-9489
DOI
10.1111/j.1085-9489.2003.03021.x
language
English
LU publication?
yes
id
c2d32ab0-408c-4fa0-8dd2-47bd5791ab63 (old id 119877)
date added to LUP
2007-07-24 16:25:15
date last changed
2018-05-29 09:42:26
@article{c2d32ab0-408c-4fa0-8dd2-47bd5791ab63,
  abstract     = {Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages. Present and previously published studies may imply that there is a time-related and type-of-injury-related profile of FK506's pro-regenerative effect.},
  author       = {Kvist, Martin and Danielsen, Nils and Dahlin, Lars},
  issn         = {1085-9489},
  language     = {eng},
  number       = {4},
  pages        = {251--259},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of the Peripheral Nervous System},
  title        = {Effects of FK506 on regeneration and macrophages in injured rat sciatic nerve.},
  url          = {http://dx.doi.org/10.1111/j.1085-9489.2003.03021.x},
  volume       = {8},
  year         = {2003},
}