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Hyperinflammation and Fibrosis in Severe COVID-19 Patients : Galectin-3, a Target Molecule to Consider

Garcia-Revilla, Juan ; Deierborg, Tomas LU ; Venero, Jose Luis and Boza-Serrano, Antonio LU (2020) In Frontiers in Immunology 11.
Abstract

COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible... (More)

COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomarker, COVID-19, cytokine storm, fibrosis, galectin-3
in
Frontiers in Immunology
volume
11
article number
2069
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85090049774
  • pmid:32973815
ISSN
1664-3224
DOI
10.3389/fimmu.2020.02069
language
English
LU publication?
yes
id
11bfea5e-9eb4-4a01-b564-097e76406f44
date added to LUP
2020-09-25 15:02:00
date last changed
2024-06-13 23:26:08
@article{11bfea5e-9eb4-4a01-b564-097e76406f44,
  abstract     = {{<p>COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.</p>}},
  author       = {{Garcia-Revilla, Juan and Deierborg, Tomas and Venero, Jose Luis and Boza-Serrano, Antonio}},
  issn         = {{1664-3224}},
  keywords     = {{biomarker; COVID-19; cytokine storm; fibrosis; galectin-3}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Immunology}},
  title        = {{Hyperinflammation and Fibrosis in Severe COVID-19 Patients : Galectin-3, a Target Molecule to Consider}},
  url          = {{http://dx.doi.org/10.3389/fimmu.2020.02069}},
  doi          = {{10.3389/fimmu.2020.02069}},
  volume       = {{11}},
  year         = {{2020}},
}