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Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements

Gromadzinska, Jolanta; Reszka, Edyta; Bruzelius, Katharina LU ; Wasowicz, Wojciech and Åkesson, Björn LU (2008) In European Journal of Nutrition 47(Suppl. 2). p.29-50
Abstract
Background The relationship between selenium and cancer involves many different aspects. These include the forms of selenium present in the diet and in the body, their functions and mechanisms of action, and methods employed in assessing an individual's selenium nutritional status-both in general, and in epidemiological studies of the risk of cancer in relation to diet, as well as in connection with long-term trials for investigating the disease-preventive potential of selenium supplementation. Aim of the review To review different aspects on selenium metabolism, the occurrence of different selenoproteins and their use as biomarkers of selenium status, the results of intervention trials of the cancer-preventive effects of selenium... (More)
Background The relationship between selenium and cancer involves many different aspects. These include the forms of selenium present in the diet and in the body, their functions and mechanisms of action, and methods employed in assessing an individual's selenium nutritional status-both in general, and in epidemiological studies of the risk of cancer in relation to diet, as well as in connection with long-term trials for investigating the disease-preventive potential of selenium supplementation. Aim of the review To review different aspects on selenium metabolism, the occurrence of different selenoproteins and their use as biomarkers of selenium status, the results of intervention trials of the cancer-preventive effects of selenium supplementation, the mechanisms of action involved, together with epidemiological findings on relations between the selenium status in the body and risk of cancer. Results and conclusions The rapid advance in the knowledge of different selenoproteins and their biological functions has opened up new possibilities for the understanding of the biological effects of selenium supplementation. A wide variety of effects of different forms and doses of selenium has been observed in a number of experimental systems, and it is at present difficult to pinpoint the mechanism that may explain the positive preventive effects of selenium supplementation observed in some human long-term trials. Moreover, additional such trials are needed to define the benefits and risks of different types and doses of selenium supplements which in the future may be implemented for public health reasons. Another necessary focus for future research is a better understanding of the mechanisms by which selenium interferes with the carcinogenesis process. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cellular actions of selenium, selenium status and cancer risk, selenoproteins, forms of selenium, chemopreventive effect of selenium
in
European Journal of Nutrition
volume
47
issue
Suppl. 2
pages
29 - 50
publisher
Springer
external identifiers
  • wos:000256260200004
  • scopus:43149094225
ISSN
1436-6215
DOI
10.1007/s00394-008-2005-z
language
English
LU publication?
yes
id
3715ffdd-4917-4907-bec3-5f7e02d833cc (old id 1201789)
date added to LUP
2008-09-16 14:06:12
date last changed
2017-08-06 03:36:02
@article{3715ffdd-4917-4907-bec3-5f7e02d833cc,
  abstract     = {Background The relationship between selenium and cancer involves many different aspects. These include the forms of selenium present in the diet and in the body, their functions and mechanisms of action, and methods employed in assessing an individual's selenium nutritional status-both in general, and in epidemiological studies of the risk of cancer in relation to diet, as well as in connection with long-term trials for investigating the disease-preventive potential of selenium supplementation. Aim of the review To review different aspects on selenium metabolism, the occurrence of different selenoproteins and their use as biomarkers of selenium status, the results of intervention trials of the cancer-preventive effects of selenium supplementation, the mechanisms of action involved, together with epidemiological findings on relations between the selenium status in the body and risk of cancer. Results and conclusions The rapid advance in the knowledge of different selenoproteins and their biological functions has opened up new possibilities for the understanding of the biological effects of selenium supplementation. A wide variety of effects of different forms and doses of selenium has been observed in a number of experimental systems, and it is at present difficult to pinpoint the mechanism that may explain the positive preventive effects of selenium supplementation observed in some human long-term trials. Moreover, additional such trials are needed to define the benefits and risks of different types and doses of selenium supplements which in the future may be implemented for public health reasons. Another necessary focus for future research is a better understanding of the mechanisms by which selenium interferes with the carcinogenesis process.},
  author       = {Gromadzinska, Jolanta and Reszka, Edyta and Bruzelius, Katharina and Wasowicz, Wojciech and Åkesson, Björn},
  issn         = {1436-6215},
  keyword      = {cellular actions of selenium,selenium status and cancer risk,selenoproteins,forms of selenium,chemopreventive effect of selenium},
  language     = {eng},
  number       = {Suppl. 2},
  pages        = {29--50},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements},
  url          = {http://dx.doi.org/10.1007/s00394-008-2005-z},
  volume       = {47},
  year         = {2008},
}