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Proteomic studies in animal models of diabetes

Resjö, Svante LU ; Berger, Karin LU ; Fex, Malin LU and Hansson, Ola LU (2008) In Proteomics Clinical Applications 2(5). p.654-669
Abstract
The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However,... (More)
The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However, to achieve this, a number of issues need to be resolved. Appropriate data representation to facilitate data comparison, exchange, and verification is required, as well as improved statistical assessment of proteomic experiments. In addition, it is important to follow up the results with functional studies to be able to make biologically relevant conclusions. The potential of proteomics to dissect complex human disorders is now beginning to be realized. In the future, this will result in new important information concerning diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
type 1/2 diabetes, diabetic treatment, animal models of diabetes, diabetic complications
in
Proteomics Clinical Applications
volume
2
issue
5
pages
654 - 669
publisher
John Wiley & Sons
external identifiers
  • wos:000256163800003
  • scopus:44649118613
ISSN
1862-8354
DOI
10.1002/prca.200780030
language
English
LU publication?
yes
id
cf358c3a-bfcc-4eec-95e0-ae97215a3931 (old id 1201992)
date added to LUP
2008-09-15 13:29:48
date last changed
2017-01-01 04:55:09
@article{cf358c3a-bfcc-4eec-95e0-ae97215a3931,
  abstract     = {The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However, to achieve this, a number of issues need to be resolved. Appropriate data representation to facilitate data comparison, exchange, and verification is required, as well as improved statistical assessment of proteomic experiments. In addition, it is important to follow up the results with functional studies to be able to make biologically relevant conclusions. The potential of proteomics to dissect complex human disorders is now beginning to be realized. In the future, this will result in new important information concerning diabetes.},
  author       = {Resjö, Svante and Berger, Karin and Fex, Malin and Hansson, Ola},
  issn         = {1862-8354},
  keyword      = {type 1/2 diabetes,diabetic treatment,animal models of diabetes,diabetic complications},
  language     = {eng},
  number       = {5},
  pages        = {654--669},
  publisher    = {John Wiley & Sons},
  series       = {Proteomics Clinical Applications},
  title        = {Proteomic studies in animal models of diabetes},
  url          = {http://dx.doi.org/10.1002/prca.200780030},
  volume       = {2},
  year         = {2008},
}