Proteomic studies in animal models of diabetes
Resjö, Svante LU ; Berger, Karin LU
; Fex, Malin
LU
and Hansson, Ola
LU
(2008)
In Proteomics Clinical Applications
2(5).
p.654-669
- Abstract
- The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However,... (More)
- The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However, to achieve this, a number of issues need to be resolved. Appropriate data representation to facilitate data comparison, exchange, and verification is required, as well as improved statistical assessment of proteomic experiments. In addition, it is important to follow up the results with functional studies to be able to make biologically relevant conclusions. The potential of proteomics to dissect complex human disorders is now beginning to be realized. In the future, this will result in new important information concerning diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1201992
- author
- Resjö, Svante
LU
; Berger, Karin
LU
; Fex, Malin
LU
and Hansson, Ola
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- type 1/2 diabetes, diabetic treatment, animal models of diabetes, diabetic complications
- in
- Proteomics Clinical Applications
- volume
- 2
- issue
- 5
- pages
- 654 - 669
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000256163800003
- scopus:44649118613
- ISSN
- 1862-8354
- DOI
- 10.1002/prca.200780030
- language
- English
- LU publication?
- yes
- id
- cf358c3a-bfcc-4eec-95e0-ae97215a3931 (old id 1201992)
- date added to LUP
- 2016-04-01 12:11:09
- date last changed
- 2022-03-21 00:39:19
@article{cf358c3a-bfcc-4eec-95e0-ae97215a3931,
abstract = {{The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However, to achieve this, a number of issues need to be resolved. Appropriate data representation to facilitate data comparison, exchange, and verification is required, as well as improved statistical assessment of proteomic experiments. In addition, it is important to follow up the results with functional studies to be able to make biologically relevant conclusions. The potential of proteomics to dissect complex human disorders is now beginning to be realized. In the future, this will result in new important information concerning diabetes.}},
author = {{Resjö, Svante and Berger, Karin and Fex, Malin and Hansson, Ola}},
issn = {{1862-8354}},
keywords = {{type 1/2 diabetes; diabetic treatment; animal models of diabetes; diabetic complications}},
language = {{eng}},
number = {{5}},
pages = {{654--669}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Proteomics Clinical Applications}},
title = {{Proteomic studies in animal models of diabetes}},
url = {{http://dx.doi.org/10.1002/prca.200780030}},
doi = {{10.1002/prca.200780030}},
volume = {{2}},
year = {{2008}},
}